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Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat

Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia. Both common carotid arteries were occluded for 20 minutes followed by rep...

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Autores principales: Sharifi, Zahra-Nadia, Abolhassani, Farid, Zarrindast, Mohammad Reza, Movassaghi, Shabnam, Rahimian, Nasrin, Hassanzadeh, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175409/
https://www.ncbi.nlm.nih.gov/pubmed/21941688
http://dx.doi.org/10.1155/2012/809417
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author Sharifi, Zahra-Nadia
Abolhassani, Farid
Zarrindast, Mohammad Reza
Movassaghi, Shabnam
Rahimian, Nasrin
Hassanzadeh, Gholamreza
author_facet Sharifi, Zahra-Nadia
Abolhassani, Farid
Zarrindast, Mohammad Reza
Movassaghi, Shabnam
Rahimian, Nasrin
Hassanzadeh, Gholamreza
author_sort Sharifi, Zahra-Nadia
collection PubMed
description Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia. Both common carotid arteries were occluded for 20 minutes followed by reperfusion. In experimental group 1, FK506 (6 mg/kg) was given as a single dose exactly at the time of reperfusion. In the second group, FK506 was administered at the beginning of reperfusion, followed by its administration intraperitoneally (IP) 6, 24, 48, and 72 hours after reperfusion. FK506 failed to show neurotrophic effects on CA1 region when applied as a single dose of 6 mg/kg. The cell number and size of the CA1 pyramidal cells were increased, also the number of cell death decreased in this region when FK506 was administrated 48 h after reperfusion. This work supports the possible use of FK506 in treatment of ischemic brain damage.
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spelling pubmed-31754092011-09-22 Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat Sharifi, Zahra-Nadia Abolhassani, Farid Zarrindast, Mohammad Reza Movassaghi, Shabnam Rahimian, Nasrin Hassanzadeh, Gholamreza Stroke Res Treat Research Article Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia. Both common carotid arteries were occluded for 20 minutes followed by reperfusion. In experimental group 1, FK506 (6 mg/kg) was given as a single dose exactly at the time of reperfusion. In the second group, FK506 was administered at the beginning of reperfusion, followed by its administration intraperitoneally (IP) 6, 24, 48, and 72 hours after reperfusion. FK506 failed to show neurotrophic effects on CA1 region when applied as a single dose of 6 mg/kg. The cell number and size of the CA1 pyramidal cells were increased, also the number of cell death decreased in this region when FK506 was administrated 48 h after reperfusion. This work supports the possible use of FK506 in treatment of ischemic brain damage. Hindawi Publishing Corporation 2012 2011-09-15 /pmc/articles/PMC3175409/ /pubmed/21941688 http://dx.doi.org/10.1155/2012/809417 Text en Copyright © 2012 Zahra-Nadia Sharifi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sharifi, Zahra-Nadia
Abolhassani, Farid
Zarrindast, Mohammad Reza
Movassaghi, Shabnam
Rahimian, Nasrin
Hassanzadeh, Gholamreza
Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title_full Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title_fullStr Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title_full_unstemmed Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title_short Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat
title_sort effects of fk506 on hippocampal ca1 cells following transient global ischemia/reperfusion in wistar rat
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175409/
https://www.ncbi.nlm.nih.gov/pubmed/21941688
http://dx.doi.org/10.1155/2012/809417
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