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The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate

BACKGROUND: Protein sequences are subject to a mosaic of constraint. Changes to functional domains and buried residues, for example, are more apt to disrupt protein structure and function than are changes to residues participating in loops or exposed to solvent. Regions of constraint on the tertiary...

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Detalles Bibliográficos
Autores principales:	McFerrin, Lisa G, Stone, Eric A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176261/ https://www.ncbi.nlm.nih.gov/pubmed/21846337 http://dx.doi.org/10.1186/1471-2164-12-415

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