Mutations in Protein-Binding Hot-Spots on the Hub Protein Smad3 Differentially Affect Its Protein Interactions and Smad3-Regulated Gene Expression

BACKGROUND: Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-β), serves as a hub protein for over 50 protein-protein interactions. Different cellular responses mediated by Smad3 ar...

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Detalles Bibliográficos
Autores principales: Schiro, Michelle M., Stauber, Sara E., Peterson, Tami L., Krueger, Chateen, Darnell, Steven J., Satyshur, Kenneth A., Drinkwater, Norman R., Newton, Michael A., Hoffmann, F. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176292/
https://www.ncbi.nlm.nih.gov/pubmed/21949838
http://dx.doi.org/10.1371/journal.pone.0025021

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