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Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
BACKGROUND: Mycobacterium tuberculosis (MTB) has been classified into 4 main lineages. Some reports have associated certain lineages with particular clinical phenotypes, but there is still insufficient information regarding the clinical and epidemiologic implications of MTB lineage variation. METHOD...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176299/ https://www.ncbi.nlm.nih.gov/pubmed/21949856 http://dx.doi.org/10.1371/journal.pone.0025075 |
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author | Albanna, Amr S. Reed, Michael B. Kotar, Kimberley V. Fallow, Ashley McIntosh, Fiona A. Behr, Marcel A. Menzies, Dick |
author_facet | Albanna, Amr S. Reed, Michael B. Kotar, Kimberley V. Fallow, Ashley McIntosh, Fiona A. Behr, Marcel A. Menzies, Dick |
author_sort | Albanna, Amr S. |
collection | PubMed |
description | BACKGROUND: Mycobacterium tuberculosis (MTB) has been classified into 4 main lineages. Some reports have associated certain lineages with particular clinical phenotypes, but there is still insufficient information regarding the clinical and epidemiologic implications of MTB lineage variation. METHODS: Using large sequence polymorphisms we classified MTB isolates from a population-based study in Montreal, Canada into the 4 major lineages, and identified the associated clinical and epidemiologic features. In addition, IS6110-RFLP and spoligotyping were used as indicators of recent TB transmission. The study population was divided into a derivation cohort, diagnosed between 2001 and 2007, and a separate validation cohort, diagnosed between 1996 and 2000. RESULTS: In the derivation cohort, when compared to the other MTB lineages, the East African-Indian (EAI) lineage was associated with lower rates of TB transmission, as measured by: positive TST among close contacts of pulmonary TB cases (adjusted odds ratio 0.6: [95% confidence interval 0.4–0.9]), and clustered TB cases (0.3: [<0.001–0.6]). Severe forms of TB were also less likely among the EAI group (0.4: [<0.001–0.8]). There were no significant differences when comparing patients with the other MTB lineages. In the validation cohort, the EAI lineage was associated with lower rates of positive TST among contacts (0.5: [0.3–0.9]) and a trend towards less clustered TB cases (0.5: [0.1–1.8]) when compared to the other lineages. Disease severity among the different groups was not significantly different in the validation cohort. CONCLUSIONS: We conclude that in Montreal, EAI strains were associated with reduced transmission compared to other MTB lineages. |
format | Online Article Text |
id | pubmed-3176299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31762992011-09-26 Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis Albanna, Amr S. Reed, Michael B. Kotar, Kimberley V. Fallow, Ashley McIntosh, Fiona A. Behr, Marcel A. Menzies, Dick PLoS One Research Article BACKGROUND: Mycobacterium tuberculosis (MTB) has been classified into 4 main lineages. Some reports have associated certain lineages with particular clinical phenotypes, but there is still insufficient information regarding the clinical and epidemiologic implications of MTB lineage variation. METHODS: Using large sequence polymorphisms we classified MTB isolates from a population-based study in Montreal, Canada into the 4 major lineages, and identified the associated clinical and epidemiologic features. In addition, IS6110-RFLP and spoligotyping were used as indicators of recent TB transmission. The study population was divided into a derivation cohort, diagnosed between 2001 and 2007, and a separate validation cohort, diagnosed between 1996 and 2000. RESULTS: In the derivation cohort, when compared to the other MTB lineages, the East African-Indian (EAI) lineage was associated with lower rates of TB transmission, as measured by: positive TST among close contacts of pulmonary TB cases (adjusted odds ratio 0.6: [95% confidence interval 0.4–0.9]), and clustered TB cases (0.3: [<0.001–0.6]). Severe forms of TB were also less likely among the EAI group (0.4: [<0.001–0.8]). There were no significant differences when comparing patients with the other MTB lineages. In the validation cohort, the EAI lineage was associated with lower rates of positive TST among contacts (0.5: [0.3–0.9]) and a trend towards less clustered TB cases (0.5: [0.1–1.8]) when compared to the other lineages. Disease severity among the different groups was not significantly different in the validation cohort. CONCLUSIONS: We conclude that in Montreal, EAI strains were associated with reduced transmission compared to other MTB lineages. Public Library of Science 2011-09-19 /pmc/articles/PMC3176299/ /pubmed/21949856 http://dx.doi.org/10.1371/journal.pone.0025075 Text en Albanna et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Albanna, Amr S. Reed, Michael B. Kotar, Kimberley V. Fallow, Ashley McIntosh, Fiona A. Behr, Marcel A. Menzies, Dick Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis |
title | Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
|
title_full | Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
|
title_fullStr | Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
|
title_full_unstemmed | Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
|
title_short | Reduced Transmissibility of East African Indian Strains of Mycobacterium tuberculosis
|
title_sort | reduced transmissibility of east african indian strains of mycobacterium tuberculosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176299/ https://www.ncbi.nlm.nih.gov/pubmed/21949856 http://dx.doi.org/10.1371/journal.pone.0025075 |
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