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AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia

Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured dayt...

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Autores principales: Klop, B., van den Berg, T. M., Rietveld, A. P., Chaves, J., Real, J. T., Ascaso, J. F., Carmena, R., Elte, J. W. F., Castro Cabezas, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176427/
https://www.ncbi.nlm.nih.gov/pubmed/21941658
http://dx.doi.org/10.1155/2012/271030
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author Klop, B.
van den Berg, T. M.
Rietveld, A. P.
Chaves, J.
Real, J. T.
Ascaso, J. F.
Carmena, R.
Elte, J. W. F.
Castro Cabezas, Manuel
author_facet Klop, B.
van den Berg, T. M.
Rietveld, A. P.
Chaves, J.
Real, J. T.
Ascaso, J. F.
Carmena, R.
Elte, J. W. F.
Castro Cabezas, Manuel
author_sort Klop, B.
collection PubMed
description Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results. Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39 ± 8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02 ± 6.20 mM*h/L) (P < 0.05). Postprandial lipemia was similar for the different C573T polymorphisms. Conclusion. The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia. These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism.
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spelling pubmed-31764272011-09-22 AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia Klop, B. van den Berg, T. M. Rietveld, A. P. Chaves, J. Real, J. T. Ascaso, J. F. Carmena, R. Elte, J. W. F. Castro Cabezas, Manuel Int J Vasc Med Clinical Study Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results. Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele (9.39 ± 8.36 mM*h/L) compared to homozygous carriers of the 1166-A allele (2.02 ± 6.20 mM*h/L) (P < 0.05). Postprandial lipemia was similar for the different C573T polymorphisms. Conclusion. The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia. These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism. Hindawi Publishing Corporation 2012 2011-09-19 /pmc/articles/PMC3176427/ /pubmed/21941658 http://dx.doi.org/10.1155/2012/271030 Text en Copyright © 2012 B. Klop et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Klop, B.
van den Berg, T. M.
Rietveld, A. P.
Chaves, J.
Real, J. T.
Ascaso, J. F.
Carmena, R.
Elte, J. W. F.
Castro Cabezas, Manuel
AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title_full AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title_fullStr AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title_full_unstemmed AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title_short AT1 Receptor Gene Polymorphisms in relation to Postprandial Lipemia
title_sort at1 receptor gene polymorphisms in relation to postprandial lipemia
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176427/
https://www.ncbi.nlm.nih.gov/pubmed/21941658
http://dx.doi.org/10.1155/2012/271030
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