The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis

Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signall...

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Detalles Bibliográficos
Autores principales: Barnes, Theresa C., Anderson, Marina E., Moots, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176444/
https://www.ncbi.nlm.nih.gov/pubmed/21941555
http://dx.doi.org/10.1155/2011/721608
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author Barnes, Theresa C.
Anderson, Marina E.
Moots, Robert J.
author_facet Barnes, Theresa C.
Anderson, Marina E.
Moots, Robert J.
author_sort Barnes, Theresa C.
collection PubMed
description Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial cell dysfunction, and fibrogenesis is discussed. The existing evidence that interventions designed to block interleukin-6 signalling are of therapeutic relevance in SSc is evaluated.
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spelling pubmed-31764442011-09-22 The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis Barnes, Theresa C. Anderson, Marina E. Moots, Robert J. Int J Rheumatol Review Article Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial cell dysfunction, and fibrogenesis is discussed. The existing evidence that interventions designed to block interleukin-6 signalling are of therapeutic relevance in SSc is evaluated. Hindawi Publishing Corporation 2011 2011-09-20 /pmc/articles/PMC3176444/ /pubmed/21941555 http://dx.doi.org/10.1155/2011/721608 Text en Copyright © 2011 Theresa C. Barnes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Barnes, Theresa C.
Anderson, Marina E.
Moots, Robert J.
The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title_full The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title_fullStr The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title_full_unstemmed The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title_short The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis
title_sort many faces of interleukin-6: the role of il-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176444/
https://www.ncbi.nlm.nih.gov/pubmed/21941555
http://dx.doi.org/10.1155/2011/721608
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