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Heteroplasmic mitochondrial DNA mutations in normal and tumor cells

The presence of hundreds of copies of mitochondrial (mt) DNA in each human cell poses a challenge for complete characterization of mtDNA genomes by conventional sequencing technologies(1). Here, we describe digital sequencing of mtDNA genomes using massively parallel sequencing-by-synthesis. Though...

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Detalles Bibliográficos
Autores principales:	He, Yiping, Wu, Jian, Dressman, Devin C., Iacobuzio-Donahue, Christine, Markowitz, Sanford D., Velculescu, Victor E., Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176451/ https://www.ncbi.nlm.nih.gov/pubmed/20200521 http://dx.doi.org/10.1038/nature08802

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