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Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men

BACKGROUND: Hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. The present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone miner...

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Autores principales: El Hadidy, El Hadidy M, Ghonaim, Mohamed, El Gawad, Soma Sh Abd, El Atta, Mohamed Abou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176471/
https://www.ncbi.nlm.nih.gov/pubmed/21819612
http://dx.doi.org/10.1186/1472-6823-11-15
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author El Hadidy, El Hadidy M
Ghonaim, Mohamed
El Gawad, Soma Sh Abd
El Atta, Mohamed Abou
author_facet El Hadidy, El Hadidy M
Ghonaim, Mohamed
El Gawad, Soma Sh Abd
El Atta, Mohamed Abou
author_sort El Hadidy, El Hadidy M
collection PubMed
description BACKGROUND: Hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. The present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (BMD). METHODS: Fifty-two male patients with hyperthyroidism, 31 with Graves' disease (GD) and 21 with toxic multinodular goiter (TNG), with an age ranging from 23 to 65 years were included, together with 25 healthy euthyroid men with matched age as a control group. In addition to full clinical examination, patients and controls were subjected to measurement of BMD using dual-energy X-ray absorptiometery scanning of the lower half of the left radius. Also, some biochemical markers of bone turnover were done for all patients and controls. RESULTS: Biochemical markers of bone turnover: included serum bone specific alkaline phosphatase, osteocalcin, carboxy terminal telopeptide of type l collagen also, urinary deoxypyridinoline cross-links (DXP), urinary DXP/urinary creatinine ratio and urinary calcium/urinary creatinine ratio were significantly higher in patients with GD and TNG compared to controls (P < 0.01). However, there was non-significant difference in these parameters between GD and TNG patients (P > 0.05). BMD was significantly lower in GD and TNG compared to controls, but the Z-score of BMD at the lower half of the left radius in patients with GD (-1.7 ± 0.5 SD) was not significantly different from those with TNG (-1.6 ± 0.6 SD) (>0.05). There was significant positive correlation between free T3 and free T4 with biochemical markers of bone turnover, but negative correlation between TSH and those biochemical markers of bone turnover. The duration of the thyrotoxic state positively correlated with the assessed bone turnover markers, but it is negatively correlated with the Z-score of BMD in the studied hyperthyroid patients (r = -0.68, P < 0.0001). CONCLUSION: Men with hyperthyroidism have significant bone loss with higher biochemical markers of bone turnover. The severity and the duration of the thyrotoxic state are directly related to the derangement of biochemical markers of bone turnover and bone loss.
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spelling pubmed-31764712011-09-21 Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men El Hadidy, El Hadidy M Ghonaim, Mohamed El Gawad, Soma Sh Abd El Atta, Mohamed Abou BMC Endocr Disord Research Article BACKGROUND: Hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. The present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (BMD). METHODS: Fifty-two male patients with hyperthyroidism, 31 with Graves' disease (GD) and 21 with toxic multinodular goiter (TNG), with an age ranging from 23 to 65 years were included, together with 25 healthy euthyroid men with matched age as a control group. In addition to full clinical examination, patients and controls were subjected to measurement of BMD using dual-energy X-ray absorptiometery scanning of the lower half of the left radius. Also, some biochemical markers of bone turnover were done for all patients and controls. RESULTS: Biochemical markers of bone turnover: included serum bone specific alkaline phosphatase, osteocalcin, carboxy terminal telopeptide of type l collagen also, urinary deoxypyridinoline cross-links (DXP), urinary DXP/urinary creatinine ratio and urinary calcium/urinary creatinine ratio were significantly higher in patients with GD and TNG compared to controls (P < 0.01). However, there was non-significant difference in these parameters between GD and TNG patients (P > 0.05). BMD was significantly lower in GD and TNG compared to controls, but the Z-score of BMD at the lower half of the left radius in patients with GD (-1.7 ± 0.5 SD) was not significantly different from those with TNG (-1.6 ± 0.6 SD) (>0.05). There was significant positive correlation between free T3 and free T4 with biochemical markers of bone turnover, but negative correlation between TSH and those biochemical markers of bone turnover. The duration of the thyrotoxic state positively correlated with the assessed bone turnover markers, but it is negatively correlated with the Z-score of BMD in the studied hyperthyroid patients (r = -0.68, P < 0.0001). CONCLUSION: Men with hyperthyroidism have significant bone loss with higher biochemical markers of bone turnover. The severity and the duration of the thyrotoxic state are directly related to the derangement of biochemical markers of bone turnover and bone loss. BioMed Central 2011-08-06 /pmc/articles/PMC3176471/ /pubmed/21819612 http://dx.doi.org/10.1186/1472-6823-11-15 Text en Copyright ©2011 El Hadidy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
El Hadidy, El Hadidy M
Ghonaim, Mohamed
El Gawad, Soma Sh Abd
El Atta, Mohamed Abou
Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title_full Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title_fullStr Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title_full_unstemmed Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title_short Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
title_sort impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176471/
https://www.ncbi.nlm.nih.gov/pubmed/21819612
http://dx.doi.org/10.1186/1472-6823-11-15
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