Cargando…

Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP

ARTS (Sept4_i2) is a mitochondrial pro-apoptotic protein that functions as a tumor suppressor. Its expression is significantly reduced in leukemia and lymphoma patients. ARTS binds and inhibits XIAP (X-linked Inhibitor of Apoptosis protein) by interacting with its Bir3 domain. ARTS promotes degradat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reingewertz, Tali H., Shalev, Deborah E., Sukenik, Shahar, Blatt, Ofrah, Rotem-Bamberger, Shahar, Lebendiker, Mario, Larisch, Sarit, Friedler, Assaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176765/ https://www.ncbi.nlm.nih.gov/pubmed/21949740 http://dx.doi.org/10.1371/journal.pone.0024655

Ejemplares similares

Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins
por: Gabizon, Ronen, et al.
Publicado: (2012)

Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism
por: Rotem-Bamberger, Shahar, et al.
Publicado: (2013)

The structure of XIAP BIR2: understanding the selectivity of the BIR domains
por: Lukacs, Christine, et al.
Publicado: (2013)

The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation
por: Dwivedi, Manish, et al.
Publicado: (2016)

Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC
por: Abbas, Ruqaia, et al.
Publicado: (2020)

Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
por: Mamriev, Dana, et al.
Publicado: (2018)

Crowding Alone Cannot Account for Cosolute Effect on Amyloid Aggregation
por: Sukenik, Shahar, et al.
Publicado: (2011)

Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1
por: Sorrentino, Luca, et al.
Publicado: (2019)

Solution structure and interaction with copper in vitro and in living cells of the first BIR domain of XIAP
por: Hou, Meng-Meng, et al.
Publicado: (2017)

Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain
por: Farag, Marc, et al.
Publicado: (2023)

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
por: Damgaard, Rune Busk, et al.
Publicado: (2013)

Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein
por: Kemeny, Stav, et al.
Publicado: (2012)

Evrenin Sırları bir bir çözülecek
Publicado: (2008)

XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion
por: Xu, Jiheng, et al.
Publicado: (2019)

Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
por: Lethier, Mathilde, et al.
Publicado: (2023)

Third BIR domain of XIAP binds to both Cu(II) and Cu(I) in multiple sites and with diverse affinities characterized at atomic resolution
por: Chen, Shen-Na, et al.
Publicado: (2019)

Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization
por: Amartely, Hadar, et al.
Publicado: (2018)

Publisher Correction: Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization
por: Amartely, Hadar, et al.
Publicado: (2019)

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2
por: Mamriev, Dana, et al.
Publicado: (2020)

Structural preferences shape the entropic force of disordered protein ensembles
por: Yu, Feng, et al.
Publicado: (2023)

Structural Preferences Shape the Entropic Force of Disordered Protein Ensembles
por: Yu, Feng, et al.
Publicado: (2023)

Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein
por: Amartely, Hadar, et al.
Publicado: (2016)

Heyecan veren bir deney
Publicado: (2008)

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell
por: Huang, Chao, et al.
Publicado: (2017)

Depresyon Tanılı Bir Hastada Fonksiyonel Sağlık Örüntüleri Modeli Temelinde Bir Bakım Planı
por: Temel, Münire, et al.
Publicado: (2019)

Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX
por: Rotem-Bamberger, Shahar, et al.
Publicado: (2022)

Versatile communication strategies among tandem WW domain repeats
por: Dodson, Emma Joy, et al.
Publicado: (2015)

Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish
por: Taler, Kineret, et al.
Publicado: (2023)

Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway
por: Smith, Michelle I., et al.
Publicado: (2009)

Highly homologous proteins exert opposite biological activities by using different interaction interfaces
por: Iosub Amir, Anat, et al.
Publicado: (2015)

BIRS – Bioterrorism Information Retrieval System
por: Tewari, Ashish Kumar, et al.
Publicado: (2013)

BIR Pipeline for Preparation of Phylogenomic Data
por: Kumar, Surendra, et al.
Publicado: (2015)

Reporter-Phage-Based Detection and Antibiotic Susceptibility Testing of Yersinia pestis for a Rapid Plague Outbreak Response
por: Moses, Sarit, et al.
Publicado: (2021)

Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma
por: Choo, Zhang'E, et al.
Publicado: (2023)

Pro-apoptotic protein–protein interactions of the extended N-AChE terminus
por: Toiber, Debra, et al.
Publicado: (2009)

Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro
por: Shahar, Or David, et al.
Publicado: (2013)

Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents
por: Klingbeil, Olaf, et al.
Publicado: (2016)

Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE
por: Cheung, Chun Hei Antonio, et al.
Publicado: (2020)

Computational modeling of protein conformational changes - Application to the opening SARS-CoV-2 spike
por: Kucherova, Anna, et al.
Publicado: (2021)

Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells
por: Sun, Haiying, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4dmgtu1njmdg72apbal7cs5trj