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Akt Regulates IL-10 Mediated Suppression of TNFα-Induced Cardiomyocyte Apoptosis by Upregulating Stat3 Phosphorylation

BACKGROUND: We have already reported that TNF-α increases cardiomyocyte apoptosis and IL-10 treatment prevented these effects of TNF-α. Present study investigates the role of Akt and Jak/Stat pathway in the IL-10 modulation of TNF-α induced cardiomyocyte apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: Ca...

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Detalles Bibliográficos
Autores principales:	Dhingra, Sanjiv, Bagchi, Ashim K., Ludke, Ana L., Sharma, Anita K., Singal, Pawan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176791/ https://www.ncbi.nlm.nih.gov/pubmed/21949832 http://dx.doi.org/10.1371/journal.pone.0025009

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