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Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir

The herpes simplex virus thymidine kinase (HSV-TK) is the most widely used suicide gene in cancer gene therapy due to its superior anticancer activity with ganciclovir compared to other HSV-TK substrates, such as 1-β-D-arabinofuranosyl thymine (araT). We have evaluated the role of DNA damage as a me...

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Detalles Bibliográficos
Autores principales:	Ladd, Brendon, O’Konek, Jessica J., Ostruszka, Leo J., Shewach, Donna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176965/ https://www.ncbi.nlm.nih.gov/pubmed/21869826 http://dx.doi.org/10.1038/cgt.2011.51

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