DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability

The abnormal number of repeats found in triplet repeat diseases arises from ‘repeat instability’, in which the repetitive section of DNA is subject to a change in copy number. Recent studies implicate transcription in a mechanism for repeat instability proposed to involve RNA polymerase II (RNAPII)...

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Detalles Bibliográficos
Autores principales: Salinas-Rios, Viviana, Belotserkovskii, Boris P., Hanawalt, Philip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177194/
https://www.ncbi.nlm.nih.gov/pubmed/21666257
http://dx.doi.org/10.1093/nar/gkr429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177194/
https://www.ncbi.nlm.nih.gov/pubmed/21666257
http://dx.doi.org/10.1093/nar/gkr429

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