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The human DEK oncogene regulates DNA damage response signaling and repair

The human DEK gene is frequently overexpressed and sometimes amplified in human cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to chemically induced papilloma formation. Additionally, DEK knockdown in vitro sensitizes cancer cells to DNA damaging agents and in...

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Detalles Bibliográficos
Autores principales:	Kavanaugh, Gina M., Wise-Draper, Trisha M., Morreale, Richard J., Morrison, Monique A., Gole, Boris, Schwemberger, Sandy, Tichy, Elisia D., Lu, Lu, Babcock, George F., Wells, James M., Drissi, Rachid, Bissler, John J., Stambrook, Peter J., Andreassen, Paul R., Wiesmüller, Lisa, Wells, Susanne I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177200/ https://www.ncbi.nlm.nih.gov/pubmed/21653549 http://dx.doi.org/10.1093/nar/gkr454

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