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A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop

The essential splicing factor Prp24 contains four RNA Recognition Motif (RRM) domains, and functions to anneal U6 and U4 RNAs during spliceosome assembly. Here, we report the structure and characterization of the C-terminal RRM4. This domain adopts a novel non-canonical RRM fold with two additional...

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Detalles Bibliográficos
Autores principales:	Martin-Tumasz, Stephen, Richie, Ashley C., Clos, Lawrence J., Brow, David A., Butcher, Samuel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177201/ https://www.ncbi.nlm.nih.gov/pubmed/21653550 http://dx.doi.org/10.1093/nar/gkr455

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