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Thrombin–aptamer recognition: a revealed ambiguity
Aptamers are structured oligonucleotides that recognize molecular targets and can function as direct protein inhibitors. The best-known example is the thrombin-binding aptamer, TBA, a single-stranded 15-mer DNA that inhibits the activity of thrombin, the key enzyme of coagulation cascade. TBA folds...
Autores principales: | Russo Krauss, Irene, Merlino, Antonello, Giancola, Concetta, Randazzo, Antonio, Mazzarella, Lelio, Sica, Filomena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177225/ https://www.ncbi.nlm.nih.gov/pubmed/21715374 http://dx.doi.org/10.1093/nar/gkr522 |
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