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Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism

Botulinum neurotoxins (BoNTs) deliver a protease to neurons which can cause a flaccid paralysis called botulism. Development of botulism antidotes will require neuronal delivery of agents that inhibit or destroy the BoNT protease. Here, we investigated the potential of engineering Clostridium diffic...

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Detalles Bibliográficos
Autores principales:	Krautz-Peterson, Greice, Zhang, Yongrong, Chen, Kevin, Oyler, George A., Feng, Hanping, Shoemaker, Charles B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177232/ https://www.ncbi.nlm.nih.gov/pubmed/21941543 http://dx.doi.org/10.1155/2012/760142

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