Cargando…

Oxidative Stress in Neurodegeneration

It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source. Although there is ample evidence from tissues of patients with neurodegenerati...

Descripción completa

Detalles Bibliográficos
Autores principales: Shukla, Varsha, Mishra, Santosh K., Pant, Harish C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177364/
https://www.ncbi.nlm.nih.gov/pubmed/21941533
http://dx.doi.org/10.1155/2011/572634
_version_ 1782212289617723392
author Shukla, Varsha
Mishra, Santosh K.
Pant, Harish C.
author_facet Shukla, Varsha
Mishra, Santosh K.
Pant, Harish C.
author_sort Shukla, Varsha
collection PubMed
description It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source. Although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological, biochemical, and molecular abnormalities in mitochondria, it is still not very clear whether the oxidative stress itself contributes to the onset of neurodegeneration or it is part of the neurodegenerative process as secondary manifestation. This paper begins with an overview of how oxidative stress occurs, discussing various oxidants and antioxidants, and role of oxidative stress in diseases in general. It highlights the role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis. The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration.
format Online
Article
Text
id pubmed-3177364
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-31773642011-09-22 Oxidative Stress in Neurodegeneration Shukla, Varsha Mishra, Santosh K. Pant, Harish C. Adv Pharmacol Sci Research Article It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source. Although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological, biochemical, and molecular abnormalities in mitochondria, it is still not very clear whether the oxidative stress itself contributes to the onset of neurodegeneration or it is part of the neurodegenerative process as secondary manifestation. This paper begins with an overview of how oxidative stress occurs, discussing various oxidants and antioxidants, and role of oxidative stress in diseases in general. It highlights the role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis. The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration. Hindawi Publishing Corporation 2011 2011-09-21 /pmc/articles/PMC3177364/ /pubmed/21941533 http://dx.doi.org/10.1155/2011/572634 Text en Copyright © 2011 Varsha Shukla et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shukla, Varsha
Mishra, Santosh K.
Pant, Harish C.
Oxidative Stress in Neurodegeneration
title Oxidative Stress in Neurodegeneration
title_full Oxidative Stress in Neurodegeneration
title_fullStr Oxidative Stress in Neurodegeneration
title_full_unstemmed Oxidative Stress in Neurodegeneration
title_short Oxidative Stress in Neurodegeneration
title_sort oxidative stress in neurodegeneration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177364/
https://www.ncbi.nlm.nih.gov/pubmed/21941533
http://dx.doi.org/10.1155/2011/572634
work_keys_str_mv AT shuklavarsha oxidativestressinneurodegeneration
AT mishrasantoshk oxidativestressinneurodegeneration
AT pantharishc oxidativestressinneurodegeneration