Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

The identification of multiple signals at individual loci could explain additional phenotypic variance (‘missing heritability’) of common traits, and help identify causal genes. We examined gene expression levels as a model trait because of the large number of strong genetic effects acting in cis. U...

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Detalles Bibliográficos
Autores principales: Wood, Andrew R., Hernandez, Dena G., Nalls, Michael A., Yaghootkar, Hanieh, Gibbs, J. Raphael, Harries, Lorna W., Chong, Sean, Moore, Matthew, Weedon, Michael N., Guralnik, Jack M., Bandinelli, Stefania, Murray, Anna, Ferrucci, Luigi, Singleton, Andrew B, Melzer, David, Frayling, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177649/
https://www.ncbi.nlm.nih.gov/pubmed/21798870
http://dx.doi.org/10.1093/hmg/ddr328

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