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Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study

OBJECTIVE: A recent meta-analysis of 13 prospective studies reported that higher levels of adiponectin were significantly associated with lower risk of type 2 diabetes. Most previous studies, however, were limited in their ability to adjust for appropriate confounding variables. Our objective, there...

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Autores principales: Hanley, Anthony J.G., Wagenknecht, Lynne E., Norris, Jill M., Bergman, Richard, Anderson, Andrea, Chen, Y. Ida, Lorenzo, Carlos, Haffner, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177725/
https://www.ncbi.nlm.nih.gov/pubmed/21816973
http://dx.doi.org/10.2337/dc11-0531
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author Hanley, Anthony J.G.
Wagenknecht, Lynne E.
Norris, Jill M.
Bergman, Richard
Anderson, Andrea
Chen, Y. Ida
Lorenzo, Carlos
Haffner, Steven M.
author_facet Hanley, Anthony J.G.
Wagenknecht, Lynne E.
Norris, Jill M.
Bergman, Richard
Anderson, Andrea
Chen, Y. Ida
Lorenzo, Carlos
Haffner, Steven M.
author_sort Hanley, Anthony J.G.
collection PubMed
description OBJECTIVE: A recent meta-analysis of 13 prospective studies reported that higher levels of adiponectin were significantly associated with lower risk of type 2 diabetes. Most previous studies, however, were limited in their ability to adjust for appropriate confounding variables. Our objective, therefore, was to study this association after adjustment for directly measured adiposity and insulin sensitivity, expressed as the insulin sensitivity index (S(I)). RESEARCH DESIGN AND METHODS: The study included 1,096 Hispanic and African American participants free of diabetes at baseline (2000–2002) who returned for follow-up after 5 years. S(I) was determined from frequently sampled intravenous glucose tolerance tests with minimal model analysis. Visceral adipose tissue (VAT) area was determined by computed tomography. Diabetes and impaired fasting glucose (IFG) were defined using American Diabetes Association criteria. Multivariate generalized estimating equation logistic regression models were used to account for correlations within families. RESULTS: A total of 82 subjects met criteria for incident diabetes. After adjustment for age, sex, ethnicity, and smoking, adiponectin was significantly inversely associated with diabetes (odds ratio [OR] 0.54 per 1 SD difference [95% CI 0.38–0.76]). The association remained significant after additional adjustment in individual models for BMI, homeostasis model assessment of insulin resistance, or VAT (all P < 0.05). However, adiponectin was no longer associated in separate models adjusted for S(I) or IFG (OR 0.81 [0.56–1.16] and 0.75 [0.53–1.06], respectively). CONCLUSIONS: Adiponectin was inversely associated with incident diabetes after adjustment for conventional anthropometric and metabolic variables or VAT. Adjustment for detailed measures of S(I) attenuated this relationship, however, suggesting that the link between adiponectin and diabetes may operate at least in part through insulin resistance.
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spelling pubmed-31777252012-10-01 Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study Hanley, Anthony J.G. Wagenknecht, Lynne E. Norris, Jill M. Bergman, Richard Anderson, Andrea Chen, Y. Ida Lorenzo, Carlos Haffner, Steven M. Diabetes Care Original Research OBJECTIVE: A recent meta-analysis of 13 prospective studies reported that higher levels of adiponectin were significantly associated with lower risk of type 2 diabetes. Most previous studies, however, were limited in their ability to adjust for appropriate confounding variables. Our objective, therefore, was to study this association after adjustment for directly measured adiposity and insulin sensitivity, expressed as the insulin sensitivity index (S(I)). RESEARCH DESIGN AND METHODS: The study included 1,096 Hispanic and African American participants free of diabetes at baseline (2000–2002) who returned for follow-up after 5 years. S(I) was determined from frequently sampled intravenous glucose tolerance tests with minimal model analysis. Visceral adipose tissue (VAT) area was determined by computed tomography. Diabetes and impaired fasting glucose (IFG) were defined using American Diabetes Association criteria. Multivariate generalized estimating equation logistic regression models were used to account for correlations within families. RESULTS: A total of 82 subjects met criteria for incident diabetes. After adjustment for age, sex, ethnicity, and smoking, adiponectin was significantly inversely associated with diabetes (odds ratio [OR] 0.54 per 1 SD difference [95% CI 0.38–0.76]). The association remained significant after additional adjustment in individual models for BMI, homeostasis model assessment of insulin resistance, or VAT (all P < 0.05). However, adiponectin was no longer associated in separate models adjusted for S(I) or IFG (OR 0.81 [0.56–1.16] and 0.75 [0.53–1.06], respectively). CONCLUSIONS: Adiponectin was inversely associated with incident diabetes after adjustment for conventional anthropometric and metabolic variables or VAT. Adjustment for detailed measures of S(I) attenuated this relationship, however, suggesting that the link between adiponectin and diabetes may operate at least in part through insulin resistance. American Diabetes Association 2011-10 2011-09-15 /pmc/articles/PMC3177725/ /pubmed/21816973 http://dx.doi.org/10.2337/dc11-0531 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Hanley, Anthony J.G.
Wagenknecht, Lynne E.
Norris, Jill M.
Bergman, Richard
Anderson, Andrea
Chen, Y. Ida
Lorenzo, Carlos
Haffner, Steven M.
Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title_full Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title_fullStr Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title_full_unstemmed Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title_short Adiponectin and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study
title_sort adiponectin and the incidence of type 2 diabetes in hispanics and african americans: the iras family study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177725/
https://www.ncbi.nlm.nih.gov/pubmed/21816973
http://dx.doi.org/10.2337/dc11-0531
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