Cargando…

Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas

Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports hav...

Descripción completa

Detalles Bibliográficos
Autores principales: Robledo, Cristina, García, Juan L., Benito, Rocío, Flores, Teresa, Mollejo, Manuela, Martínez-Climent, José Ángel, García, Eva, Gutiérrez, Norma C., Piris, Miguel A., Hernández, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177857/
https://www.ncbi.nlm.nih.gov/pubmed/21957467
http://dx.doi.org/10.1371/journal.pone.0024939
_version_ 1782212342131458048
author Robledo, Cristina
García, Juan L.
Benito, Rocío
Flores, Teresa
Mollejo, Manuela
Martínez-Climent, José Ángel
García, Eva
Gutiérrez, Norma C.
Piris, Miguel A.
Hernández, Jesús M.
author_facet Robledo, Cristina
García, Juan L.
Benito, Rocío
Flores, Teresa
Mollejo, Manuela
Martínez-Climent, José Ángel
García, Eva
Gutiérrez, Norma C.
Piris, Miguel A.
Hernández, Jesús M.
author_sort Robledo, Cristina
collection PubMed
description Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have located this loss in the 7q32 region. In order to better characterize the genomic imbalances in SMZL, molecular studies were carried out in 73 patients with SMZL. To gain insight into the mapping at 7q a tiling array was also used. The results confirmed the loss of 7q as the most frequent change. In addition, several abnormalities, including 4q22.1, 1q21.3–q22, 6q25.3, 20q13.33, 3q28, 2q23.3–q24.1 and 17p13, were also present. A loss of 7q22.1 at 99925039–101348479 bp was observed in half of the cases. The region of 7q22.1 has not previously been characterised in SMZL. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL.
format Online
Article
Text
id pubmed-3177857
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-31778572011-09-28 Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas Robledo, Cristina García, Juan L. Benito, Rocío Flores, Teresa Mollejo, Manuela Martínez-Climent, José Ángel García, Eva Gutiérrez, Norma C. Piris, Miguel A. Hernández, Jesús M. PLoS One Research Article Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have located this loss in the 7q32 region. In order to better characterize the genomic imbalances in SMZL, molecular studies were carried out in 73 patients with SMZL. To gain insight into the mapping at 7q a tiling array was also used. The results confirmed the loss of 7q as the most frequent change. In addition, several abnormalities, including 4q22.1, 1q21.3–q22, 6q25.3, 20q13.33, 3q28, 2q23.3–q24.1 and 17p13, were also present. A loss of 7q22.1 at 99925039–101348479 bp was observed in half of the cases. The region of 7q22.1 has not previously been characterised in SMZL. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL. Public Library of Science 2011-09-21 /pmc/articles/PMC3177857/ /pubmed/21957467 http://dx.doi.org/10.1371/journal.pone.0024939 Text en Robledo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Robledo, Cristina
García, Juan L.
Benito, Rocío
Flores, Teresa
Mollejo, Manuela
Martínez-Climent, José Ángel
García, Eva
Gutiérrez, Norma C.
Piris, Miguel A.
Hernández, Jesús M.
Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title_full Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title_fullStr Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title_full_unstemmed Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title_short Molecular Characterization of the Region 7q22.1 in Splenic Marginal Zone Lymphomas
title_sort molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177857/
https://www.ncbi.nlm.nih.gov/pubmed/21957467
http://dx.doi.org/10.1371/journal.pone.0024939
work_keys_str_mv AT robledocristina molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT garciajuanl molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT benitorocio molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT floresteresa molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT mollejomanuela molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT martinezclimentjoseangel molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT garciaeva molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT gutierreznormac molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT pirismiguela molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
AT hernandezjesusm molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas