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Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report

INTRODUCTION: Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported. CASE PRESENTATION: The diagnosis of systemic lupus erythematosus was made in a 15-year-old Caucasian girl...

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Autor principal: Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177938/
https://www.ncbi.nlm.nih.gov/pubmed/21899757
http://dx.doi.org/10.1186/1752-1947-5-443
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author Anders, Hans-Joachim
author_facet Anders, Hans-Joachim
author_sort Anders, Hans-Joachim
collection PubMed
description INTRODUCTION: Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported. CASE PRESENTATION: The diagnosis of systemic lupus erythematosus was made in a 15-year-old Caucasian girl based on otherwise unexplained fatigue, arthralgia, tenosynovitis, leukopenia, low platelets and the presence of antinuclear and deoxyribonucleic antibodies. At the age of 20 a renal biopsy revealed lupus nephritis class IV and she went into complete remission with mycophenolate mofetil and steroids. She was kept on mycophenolate mofetil for maintenance therapy. At the age of 24 she experienced a flare-up of lupus nephritis with nephrotic syndrome and new onset of pain in her right hip. Magnetic resonance imaging, arthroscopy and subtotal synovectomy identified pigmented villonodular synovitis as the underlying diagnosis. Although her systemic lupus erythematosus went into remission with another course of steroids and higher doses of mycophenolate mofetil, the pigmented villonodular synovitis persisted and she had to undergo open synovectomy to control her symptoms. CONCLUSION: Systemic lupus erythematosus is associated with many different musculoskeletal manifestations including synovitis and arthritis. Pigmented villonodular synovitis has not previously been reported in association with systemic lupus erythematosus, but as its etiology is still unknown, the present case raises the question about a causal relationship between systemic lupus erythematosus and pigmented villonodular synovitis.
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spelling pubmed-31779382011-09-22 Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report Anders, Hans-Joachim J Med Case Reports Case Report INTRODUCTION: Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported. CASE PRESENTATION: The diagnosis of systemic lupus erythematosus was made in a 15-year-old Caucasian girl based on otherwise unexplained fatigue, arthralgia, tenosynovitis, leukopenia, low platelets and the presence of antinuclear and deoxyribonucleic antibodies. At the age of 20 a renal biopsy revealed lupus nephritis class IV and she went into complete remission with mycophenolate mofetil and steroids. She was kept on mycophenolate mofetil for maintenance therapy. At the age of 24 she experienced a flare-up of lupus nephritis with nephrotic syndrome and new onset of pain in her right hip. Magnetic resonance imaging, arthroscopy and subtotal synovectomy identified pigmented villonodular synovitis as the underlying diagnosis. Although her systemic lupus erythematosus went into remission with another course of steroids and higher doses of mycophenolate mofetil, the pigmented villonodular synovitis persisted and she had to undergo open synovectomy to control her symptoms. CONCLUSION: Systemic lupus erythematosus is associated with many different musculoskeletal manifestations including synovitis and arthritis. Pigmented villonodular synovitis has not previously been reported in association with systemic lupus erythematosus, but as its etiology is still unknown, the present case raises the question about a causal relationship between systemic lupus erythematosus and pigmented villonodular synovitis. BioMed Central 2011-09-07 /pmc/articles/PMC3177938/ /pubmed/21899757 http://dx.doi.org/10.1186/1752-1947-5-443 Text en Copyright ©2011 Anders; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Anders, Hans-Joachim
Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title_full Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title_fullStr Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title_full_unstemmed Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title_short Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
title_sort pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177938/
https://www.ncbi.nlm.nih.gov/pubmed/21899757
http://dx.doi.org/10.1186/1752-1947-5-443
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