When orthologs diverge between human and mouse

Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understa...

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Detalles Bibliográficos
Autores principales: Gharib, Walid H., Robinson-Rechavi, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Special Issue Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178054/
https://www.ncbi.nlm.nih.gov/pubmed/21677033
http://dx.doi.org/10.1093/bib/bbr031
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author Gharib, Walid H.
Robinson-Rechavi, Marc
author_facet Gharib, Walid H.
Robinson-Rechavi, Marc
author_sort Gharib, Walid H.
collection PubMed
description Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.
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spelling pubmed-31780542011-09-22 When orthologs diverge between human and mouse Gharib, Walid H. Robinson-Rechavi, Marc Brief Bioinform Special Issue Papers Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research. Oxford University Press 2011-09 2011-06-15 /pmc/articles/PMC3178054/ /pubmed/21677033 http://dx.doi.org/10.1093/bib/bbr031 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Papers
Gharib, Walid H.
Robinson-Rechavi, Marc
When orthologs diverge between human and mouse
title When orthologs diverge between human and mouse
title_full When orthologs diverge between human and mouse
title_fullStr When orthologs diverge between human and mouse
title_full_unstemmed When orthologs diverge between human and mouse
title_short When orthologs diverge between human and mouse
title_sort when orthologs diverge between human and mouse
topic Special Issue Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178054/
https://www.ncbi.nlm.nih.gov/pubmed/21677033
http://dx.doi.org/10.1093/bib/bbr031
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