The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia

The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα   in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation...

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Detalles Bibliográficos
Autores principales: Chen, Shujie, Zhong, Jing, Zhou, Qunyan, Lu, Xiaofeng, Wang, Liangjing, Si, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178109/
https://www.ncbi.nlm.nih.gov/pubmed/21949663
http://dx.doi.org/10.1155/2011/403956
Descripción
Sumario:The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα   in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dramatically decreased (P < 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P < 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P < 0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats.

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