Cargando…
Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation
OBJECTIVE: PKC-ζ activation is a key signaling event for growth factor–induced β-cell replication in vitro. However, the effect of direct PKC-ζ activation in the β-cell in vivo is unknown. In this study, we examined the effects of PKC-ζ activation in β-cell expansion and function in vivo in mice and...
Autores principales: | Velazquez-Garcia, Silvia, Valle, Shelley, Rosa, Taylor C., Takane, Karen K., Demirci, Cem, Alvarez-Perez, Juan C., Mellado-Gil, Jose M., Ernst, Sara, Scott, Donald K., Vasavada, Rupangi C., Alonso, Laura C., Garcia-Ocaña, Adolfo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178296/ https://www.ncbi.nlm.nih.gov/pubmed/21911744 http://dx.doi.org/10.2337/db10-1783 |
Ejemplares similares
-
PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2
por: Lakshmipathi, Jayalakshmi, et al.
Publicado: (2016) -
Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
por: Mellado-Gil, Jose, et al.
Publicado: (2011) -
Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
por: Demirci, Cem, et al.
Publicado: (2012) -
Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration
por: Alvarez-Perez, Juan Carlos, et al.
Publicado: (2014) -
Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression
por: Guthalu Kondegowda, Nagesha, et al.
Publicado: (2010)