Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2...

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Autores principales: Strawbridge, Rona J., Dupuis, Josée, Prokopenko, Inga, Barker, Adam, Ahlqvist, Emma, Rybin, Denis, Petrie, John R., Travers, Mary E., Bouatia-Naji, Nabila, Dimas, Antigone S., Nica, Alexandra, Wheeler, Eleanor, Chen, Han, Voight, Benjamin F., Taneera, Jalal, Kanoni, Stavroula, Peden, John F., Turrini, Fabiola, Gustafsson, Stefan, Zabena, Carina, Almgren, Peter, Barker, David J.P., Barnes, Daniel, Dennison, Elaine M., Eriksson, Johan G., Eriksson, Per, Eury, Elodie, Folkersen, Lasse, Fox, Caroline S., Frayling, Timothy M., Goel, Anuj, Gu, Harvest F., Horikoshi, Momoko, Isomaa, Bo, Jackson, Anne U., Jameson, Karen A., Kajantie, Eero, Kerr-Conte, Julie, Kuulasmaa, Teemu, Kuusisto, Johanna, Loos, Ruth J.F., Luan, Jian'an, Makrilakis, Konstantinos, Manning, Alisa K., Martínez-Larrad, María Teresa, Narisu, Narisu, Nastase Mannila, Maria, Öhrvik, John, Osmond, Clive, Pascoe, Laura, Payne, Felicity, Sayer, Avan A., Sennblad, Bengt, Silveira, Angela, Stančáková, Alena, Stirrups, Kathy, Swift, Amy J., Syvänen, Ann-Christine, Tuomi, Tiinamaija, van 't Hooft, Ferdinand M., Walker, Mark, Weedon, Michael N., Xie, Weijia, Zethelius, Björn, Ongen, Halit, Mälarstig, Anders, Hopewell, Jemma C., Saleheen, Danish, Chambers, John, Parish, Sarah, Danesh, John, Kooner, Jaspal, Östenson, Claes-Göran, Lind, Lars, Cooper, Cyrus C., Serrano-Ríos, Manuel, Ferrannini, Ele, Forsen, Tom J., Clarke, Robert, Franzosi, Maria Grazia, Seedorf, Udo, Watkins, Hugh, Froguel, Philippe, Johnson, Paul, Deloukas, Panos, Collins, Francis S., Laakso, Markku, Dermitzakis, Emmanouil T., Boehnke, Michael, McCarthy, Mark I., Wareham, Nicholas J., Groop, Leif, Pattou, François, Gloyn, Anna L., Dedoussis, George V., Lyssenko, Valeriya, Meigs, James B., Barroso, Inês, Watanabe, Richard M., Ingelsson, Erik, Langenberg, Claudia, Hamsten, Anders, Florez, Jose C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178302/
https://www.ncbi.nlm.nih.gov/pubmed/21873549
http://dx.doi.org/10.2337/db11-0415

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