Cargando…

Substrate-modulated gating dynamics in a Na(+)-coupled neurotransmitter transporter homolog

Detalles Bibliográficos
Autores principales:	Zhao, Yongfang, Terry, Daniel, Shi, Lei, Quick, Matthias, Weinstein, Harel, Blanchard, Scott C., Javitch, Jonathan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178346/ https://www.ncbi.nlm.nih.gov/pubmed/21516104 http://dx.doi.org/10.1038/nature09971

Ejemplares similares

Single-molecule dynamics of gating in a neurotransmitter transporter homolog
por: Zhao, Yongfang, et al.
Publicado: (2010)

Substrate-dependent proton antiport in neurotransmitter:sodium symporters
por: Zhao, Yongfang, et al.
Publicado: (2009)

Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
por: Stolzenberg, Sebastian, et al.
Publicado: (2015)

A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport
por: Terry, Daniel S., et al.
Publicado: (2018)

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
por: LeVine, Michael V., et al.
Publicado: (2019)

Structure and Gating Dynamics of Na(+)/Cl(–) Coupled Neurotransmitter Transporters
por: Joseph, Deepthi, et al.
Publicado: (2019)

On the Role of a Conserved Methionine in the Na(+)-Coupling Mechanism of a Neurotransmitter Transporter Homolog
por: Zhou, Wenchang, et al.
Publicado: (2021)

The Substrate-Driven Transition to an Inward-Facing Conformation in the Functional Mechanism of the Dopamine Transporter
por: Shan, Jufang, et al.
Publicado: (2011)

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles
por: LeVine, Michael V., et al.
Publicado: (2016)

Na(+)-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters
por: Alleva, C., et al.
Publicado: (2020)

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
por: Gotfryd, Kamil, et al.
Publicado: (2020)

Experimental conditions can obscure the second high-affinity site in LeuT
por: Quick, Matthias, et al.
Publicado: (2012)

The molecular logic of sodium-coupled neurotransmitter transporters
por: Gouaux, Eric
Publicado: (2008)

The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site
por: Khelashvili, George, et al.
Publicado: (2013)

Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters
por: Jayaraman, Kumaresan, et al.
Publicado: (2012)

Allosteric gate modulation confers K(+) coupling in glutamate transporters
por: Kortzak, Daniel, et al.
Publicado: (2019)

Conformational dynamics of ligand-dependent alternating access in LeuT
por: Kazmier, Kelli, et al.
Publicado: (2014)

Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy
por: Niello, Marco, et al.
Publicado: (2020)

Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation
por: Han, Yang, et al.
Publicado: (2009)

Structural basis of ion – substrate coupling in the Na(+)-dependent dicarboxylate transporter VcINDY
por: Sauer, David B., et al.
Publicado: (2022)

Distinct roles of the Na(+) binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, Glt(Ph)
por: Riederer, Erika A., et al.
Publicado: (2022)

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh
por: Stolzenberg, Sebastian, et al.
Publicado: (2012)

Na(+)/K(+)-pump and neurotransmitter membrane receptors
por: Pivovarov, Arkady S., et al.
Publicado: (2018)

Modeling and Dynamics of the Inward-Facing State of a Na(+)/Cl(−) Dependent Neurotransmitter Transporter Homologue
por: Shaikh, Saher Afshan, et al.
Publicado: (2010)

Direct neurotransmitter activation of voltage-gated potassium channels
por: Manville, Rían W., et al.
Publicado: (2018)

Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder
por: Ciftci, Didar, et al.
Publicado: (2020)

Structure and electromechanical coupling of a voltage-gated Na(+)/H(+) exchanger
por: Yeo, Hyunku, et al.
Publicado: (2023)

Bile acid interactions with neurotransmitter transporters
por: Romanazzi, Tiziana, et al.
Publicado: (2023)

Differential Sialylation Modulates Voltage-gated Na(+) Channel Gating throughout the Developing Myocardium
por: Stocker, Patrick J., et al.
Publicado: (2006)

Transport domain unlocking sets the uptake rate of an aspartate transporter
por: Akyuz, Nurunisa, et al.
Publicado: (2015)

Electrogenicity of Na(+)-coupled bile acid transporters.
por: Weinman, S. A.
Publicado: (1997)

Isoflurane modulates activation and inactivation gating of the prokaryotic Na(+) channel NaChBac
por: Sand, Rheanna M., et al.
Publicado: (2017)

Extracellular intersubunit interactions modulate epithelial Na(+) channel gating
por: Zhang, Lei, et al.
Publicado: (2023)

GRKs as Modulators of Neurotransmitter Receptors
por: Gurevich, Eugenia V., et al.
Publicado: (2020)

Gating of TonB-dependent transporters by substrate-specific forced remodelling
por: Hickman, Samuel J., et al.
Publicado: (2017)

The putative Na(+)/Cl(−)-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis
por: Luan, Zhuo, et al.
Publicado: (2015)

Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
por: Pidathala, Shabareesh, et al.
Publicado: (2021)

Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters in Drosophila
por: Nässel, Dick R.
Publicado: (2018)

Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters
por: Zhao, Qin, et al.
Publicado: (2015)

Propofol inhibits prokaryotic voltage-gated Na(+) channels by promoting activation-coupled inactivation
por: Yang, Elaine, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9fcj68driqchi3rj3r2nf66ltk