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Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?

Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macrophages). These types of cells are thought to eith...

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Autores principales: Huysentruyt, Leanne C, Akgoc, Zeynep, Seyfried, Thomas N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178415/
https://www.ncbi.nlm.nih.gov/pubmed/21834792
http://dx.doi.org/10.1042/AN20110011
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author Huysentruyt, Leanne C
Akgoc, Zeynep
Seyfried, Thomas N
author_facet Huysentruyt, Leanne C
Akgoc, Zeynep
Seyfried, Thomas N
author_sort Huysentruyt, Leanne C
collection PubMed
description Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macrophages). These types of cells are thought to either enhance or inhibit brain tumour progression. Recent evidence indicates that neoplastic cells with macrophage characteristics are found in numerous metastatic cancers of non-CNS (central nervous system) origin. Evidence is presented here suggesting that subpopulations of cells within human gliomas, specifically GBM (glioblastoma multiforme), are neoplastic macrophages/microglia. These cells are thought to arise following mitochondrial damage in fusion hybrids between neoplastic stem cells and macrophages/microglia.
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spelling pubmed-31784152011-09-27 Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? Huysentruyt, Leanne C Akgoc, Zeynep Seyfried, Thomas N ASN Neuro Review Article Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macrophages). These types of cells are thought to either enhance or inhibit brain tumour progression. Recent evidence indicates that neoplastic cells with macrophage characteristics are found in numerous metastatic cancers of non-CNS (central nervous system) origin. Evidence is presented here suggesting that subpopulations of cells within human gliomas, specifically GBM (glioblastoma multiforme), are neoplastic macrophages/microglia. These cells are thought to arise following mitochondrial damage in fusion hybrids between neoplastic stem cells and macrophages/microglia. American Society for Neurochemistry 2011-09-22 /pmc/articles/PMC3178415/ /pubmed/21834792 http://dx.doi.org/10.1042/AN20110011 Text en © 2011 The Author(s). http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Huysentruyt, Leanne C
Akgoc, Zeynep
Seyfried, Thomas N
Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title_full Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title_fullStr Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title_full_unstemmed Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title_short Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
title_sort hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178415/
https://www.ncbi.nlm.nih.gov/pubmed/21834792
http://dx.doi.org/10.1042/AN20110011
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