Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells

Inhibiting Hsp90 chaperone roles using 17AAG induces cytostasis or apoptosis in tumor cells through destabilization of several mutated cancer promoting proteins. Although mitochondria are central in deciding the fate of cells, 17AAG induced effects on tumor cell mitochondria were largely unknown. He...

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Detalles Bibliográficos
Autores principales: Vishal, Chaturvedi, Kumar, Jonnala Ujwal, Veera Brahmendra Swamy, Cherukuvada, Nandini, Rangaraj, Srinivas, Gunda, Kumaresan, Rathinam, Shashi, Singh, Sreedhar, Amere Subbarao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178438/
https://www.ncbi.nlm.nih.gov/pubmed/22087060
http://dx.doi.org/10.4137/DTI.S6582

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