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Hepatitis C virus genotypes in Pakistan: a systemic review
BACKGROUND AND AIM: Phylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmissio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178528/ https://www.ncbi.nlm.nih.gov/pubmed/21902822 http://dx.doi.org/10.1186/1743-422X-8-433 |
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author | Attaullah, Sobia Khan, Sanaullah Ali, Ijaz |
author_facet | Attaullah, Sobia Khan, Sanaullah Ali, Ijaz |
author_sort | Attaullah, Sobia |
collection | PubMed |
description | BACKGROUND AND AIM: Phylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. This article deepens the current molecular information about the geographical distribution of HCV genotypes and subgenotypes in population of four provinces of Pakistan. 34 published papers (1996-2011) related to prevalence of HCV genotypes/serotypes and subgenotypes in Pakistan were searched. RESULT: HCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces. |
format | Online Article Text |
id | pubmed-3178528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31785282011-09-23 Hepatitis C virus genotypes in Pakistan: a systemic review Attaullah, Sobia Khan, Sanaullah Ali, Ijaz Virol J Review BACKGROUND AND AIM: Phylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. This article deepens the current molecular information about the geographical distribution of HCV genotypes and subgenotypes in population of four provinces of Pakistan. 34 published papers (1996-2011) related to prevalence of HCV genotypes/serotypes and subgenotypes in Pakistan were searched. RESULT: HCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces. BioMed Central 2011-09-08 /pmc/articles/PMC3178528/ /pubmed/21902822 http://dx.doi.org/10.1186/1743-422X-8-433 Text en Copyright ©2011 Attaullah et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Attaullah, Sobia Khan, Sanaullah Ali, Ijaz Hepatitis C virus genotypes in Pakistan: a systemic review |
title | Hepatitis C virus genotypes in Pakistan: a systemic review |
title_full | Hepatitis C virus genotypes in Pakistan: a systemic review |
title_fullStr | Hepatitis C virus genotypes in Pakistan: a systemic review |
title_full_unstemmed | Hepatitis C virus genotypes in Pakistan: a systemic review |
title_short | Hepatitis C virus genotypes in Pakistan: a systemic review |
title_sort | hepatitis c virus genotypes in pakistan: a systemic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178528/ https://www.ncbi.nlm.nih.gov/pubmed/21902822 http://dx.doi.org/10.1186/1743-422X-8-433 |
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