Cargando…

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptor family of ligand-inducible transcription factors, which have three different isoforms: PPARα, δ and γ. It has been demonstrated that PPARα and γ agonists have renoprotective effects in proteinuric kidney diseases; however, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xu, Kume, Shinji, Tanaka, Yuki, Isshiki, Keiji, Araki, Shin-ichi, Chin-Kanasaki, Masami, Sugimoto, Toshiro, Koya, Daisuke, Haneda, Masakazu, Sugaya, Takeshi, Li, Detian, Han, Ping, Nishio, Yoshihiko, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178624/ https://www.ncbi.nlm.nih.gov/pubmed/21966476 http://dx.doi.org/10.1371/journal.pone.0025271

Ejemplares similares

Arterial stiffness and renal impairment in non‐proteinuric type 2 diabetic patients
por: Nakao, Keiko, et al.
Publicado: (2011)

Predictive Effects of Urinary Liver-Type Fatty Acid–Binding Protein for Deteriorating Renal Function and Incidence of Cardiovascular Disease in Type 2 Diabetic Patients Without Advanced Nephropathy
por: Araki, Shin-ichi, et al.
Publicado: (2013)

Association Between Urinary Type IV Collagen Level and Deterioration of Renal Function in Type 2 Diabetic Patients Without Overt Proteinuria
por: Araki, Shin-ichi, et al.
Publicado: (2010)

Effects of blood pressure and the renin‐angiotensin system on platelet activation in type 2 diabetes
por: Uzu, Takashi, et al.
Publicado: (2010)

Efficacy and tolerability of vildagliptin in type 2 diabetic patients on hemodialysis
por: Kume, Shinji, et al.
Publicado: (2012)

Cilostazol Attenuates Spontaneous Microaggregation of Platelets in Type 2 Diabetic Patients With Insufficient Platelet Response to Aspirin
por: Araki, Shin-ichi, et al.
Publicado: (2013)

Correlation Between Albuminuria and Spontaneous Platelet Microaggregate Formation in Type 2 Diabetic Patients
por: Araki, Shin-ichi, et al.
Publicado: (2009)

Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes
por: Kume, Shinji, et al.
Publicado: (2016)

Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014
por: Kume, Shinji, et al.
Publicado: (2019)

Predictive Properties of Plasma Amino Acid Profile for Cardiovascular Disease in Patients with Type 2 Diabetes
por: Kume, Shinji, et al.
Publicado: (2014)

The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus
por: Zhou, Jun, et al.
Publicado: (2020)

Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats
por: Yazdani, Saleh, et al.
Publicado: (2015)

Oral glucose‐stimulated serum C‐peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment
por: Araki, Hisazumi, et al.
Publicado: (2013)

Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus
por: Sawaguchi, Makoto, et al.
Publicado: (2012)

Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy
por: Araki, Hisazumi, et al.
Publicado: (2013)

Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells
por: Iwai, Tamaki, et al.
Publicado: (2016)

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
por: Defaux, Antoinette, et al.
Publicado: (2009)

A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice
por: Chen, Wei, et al.
Publicado: (2015)

The PPARδ Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells
por: Clark, Jordan, et al.
Publicado: (2009)

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation
por: Takagi, Ayano, et al.
Publicado: (2016)

Autophagy as a Therapeutic Target in Diabetic Nephropathy
por: Tanaka, Yuki, et al.
Publicado: (2012)

GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice
por: Magliano, D'Angelo Carlo, et al.
Publicado: (2015)

Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2008)

Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure
por: Elie-Caille, Céline, et al.
Publicado: (2020)

Impact of obesity on annual medical expenditures and diabetes care in Japanese patients with type 2 diabetes mellitus
por: Kusunoki‐Tsuji, Chisato, et al.
Publicado: (2017)

A dialysis patient with hyperammonaemia: inferior mesenteric-caval shunt as a cause of portal-systemic encephalopathy
por: Izumiya-Iwai, Tamaki, et al.
Publicado: (2011)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis
por: Ji, Yangyang, et al.
Publicado: (2018)

PPARδ Agonist GW501516 Suppresses the TGF-β-Induced Profibrotic Response of Human Bronchial Fibroblasts from Asthmatic Patients
por: Paw, Milena, et al.
Publicado: (2023)

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
por: Kume, Shinji, et al.
Publicado: (2014)

PPARδ Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling
por: Liu, Guangjie, et al.
Publicado: (2013)

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
por: Kostadinova, Radina, et al.
Publicado: (2012)

The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos
por: Idrees, Muhammad, et al.
Publicado: (2019)

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
por: Smith, Russell W., et al.
Publicado: (2016)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206
por: Gu, Linglan, et al.
Publicado: (2019)

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
por: Yamahara, Kosuke, et al.
Publicado: (2013)

Sodium–glucose cotransporter 2 inhibitors represent a paradigm shift in the prevention of heart failure in type 2 diabetes patients
por: Kashiwagi, Atsunori, et al.
Publicado: (2020)

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
por: Rivera, Caroline N., et al.
Publicado: (2023)

Successful Renal Replacement Therapy for a Patient with Severe Hemophilia after Surgical Treatment of Intracranial Hemorrhage and Hydrocephalus
por: Kato, Noriko, et al.
Publicado: (2011)

Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes
por: Maeda, Shiro, et al.
Publicado: (2011)

Non-Proteinuric Diabetic Nephropathy
por: Robles, Nicolas Roberto, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_asmn7cevp0mic2j1fa622t318v