A Monoclonal Antibody to O-Acetyl-GD2 Ganglioside and Not to GD2 Shows Potent Anti-Tumor Activity without Peripheral Nervous System Cross-Reactivity

BACKGROUND: Monoclonal antibodies (mAb) against GD2 ganglioside have been shown to be effective for the treatment of neuroblastoma. Beneficial actions are, however, associated with generalized pain due to the binding of anti- GD2 mAbs to peripheral nerve fibers followed by complement activation. Neu...

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Detalles Bibliográficos
Autores principales: Alvarez-Rueda, Nidia, Desselle, Ariane, Cochonneau, Denis, Chaumette, Tanguy, Clemenceau, Béatrice, Leprieur, Stéphanie, Bougras, Gwenola, Supiot, Stéphane, Mussini, Jean-Marie, Barbet, Jacques, Saba, Julie, Paris, François, Aubry, Jacques, Birklé, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178631/
https://www.ncbi.nlm.nih.gov/pubmed/21966461
http://dx.doi.org/10.1371/journal.pone.0025220

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