Polymeric Gene Delivery for Diabetic Treatment

Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (...

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Detalles Bibliográficos
Autor principal: Kim, Sung Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178691/
https://www.ncbi.nlm.nih.gov/pubmed/21977450
http://dx.doi.org/10.4093/dmj.2011.35.4.317
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author Kim, Sung Wan
author_facet Kim, Sung Wan
author_sort Kim, Sung Wan
collection PubMed
description Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
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spelling pubmed-31786912011-10-04 Polymeric Gene Delivery for Diabetic Treatment Kim, Sung Wan Diabetes Metab J Review Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal. Korean Diabetes Association 2011-08 2011-08-31 /pmc/articles/PMC3178691/ /pubmed/21977450 http://dx.doi.org/10.4093/dmj.2011.35.4.317 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Sung Wan
Polymeric Gene Delivery for Diabetic Treatment
title Polymeric Gene Delivery for Diabetic Treatment
title_full Polymeric Gene Delivery for Diabetic Treatment
title_fullStr Polymeric Gene Delivery for Diabetic Treatment
title_full_unstemmed Polymeric Gene Delivery for Diabetic Treatment
title_short Polymeric Gene Delivery for Diabetic Treatment
title_sort polymeric gene delivery for diabetic treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178691/
https://www.ncbi.nlm.nih.gov/pubmed/21977450
http://dx.doi.org/10.4093/dmj.2011.35.4.317
work_keys_str_mv AT kimsungwan polymericgenedeliveryfordiabetictreatment

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