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Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients

BACKGROUND: Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasc...

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Autores principales: Chung, Jin Ook, Cho, Dong Hyeok, Chung, Dong Jin, Chung, Min Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178700/
https://www.ncbi.nlm.nih.gov/pubmed/21977459
http://dx.doi.org/10.4093/dmj.2011.35.4.390
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author Chung, Jin Ook
Cho, Dong Hyeok
Chung, Dong Jin
Chung, Min Young
author_facet Chung, Jin Ook
Cho, Dong Hyeok
Chung, Dong Jin
Chung, Min Young
author_sort Chung, Jin Ook
collection PubMed
description BACKGROUND: Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasculopathy have been suggested. We aimed to assess associations between DPN and cardiovascular complications in type 2 diabetic patients. METHODS: Microvascular and cardiovascular complications were evaluated in 1,041 type 2 diabetic patients. RESULTS: In patients with DPN, the age, prevalence of hypertension, diabetes duration, systolic blood pressure, pulse pressure, and hemoglobin glycation (HbA1c) levels were significantly higher, while the high density lipoprotein cholesterol (HDL-C) levels were lower than in those without DPN. The prevalence of CVD was higher in patients with DPN. In multivariate analysis, DPN was independently associated with CVD (odds ratio, 1.801; 95% confidence interval, 1.009 to 3.214). CONCLUSION: Our results showed that DPN was associated with a high prevalence of cardiovascular disease in type 2 diabetic patients, but further studies are needed to investigate the causative nature of associations between DPN and CVD.
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spelling pubmed-31787002011-10-04 Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients Chung, Jin Ook Cho, Dong Hyeok Chung, Dong Jin Chung, Min Young Diabetes Metab J Original Article BACKGROUND: Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasculopathy have been suggested. We aimed to assess associations between DPN and cardiovascular complications in type 2 diabetic patients. METHODS: Microvascular and cardiovascular complications were evaluated in 1,041 type 2 diabetic patients. RESULTS: In patients with DPN, the age, prevalence of hypertension, diabetes duration, systolic blood pressure, pulse pressure, and hemoglobin glycation (HbA1c) levels were significantly higher, while the high density lipoprotein cholesterol (HDL-C) levels were lower than in those without DPN. The prevalence of CVD was higher in patients with DPN. In multivariate analysis, DPN was independently associated with CVD (odds ratio, 1.801; 95% confidence interval, 1.009 to 3.214). CONCLUSION: Our results showed that DPN was associated with a high prevalence of cardiovascular disease in type 2 diabetic patients, but further studies are needed to investigate the causative nature of associations between DPN and CVD. Korean Diabetes Association 2011-08 2011-08-31 /pmc/articles/PMC3178700/ /pubmed/21977459 http://dx.doi.org/10.4093/dmj.2011.35.4.390 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Jin Ook
Cho, Dong Hyeok
Chung, Dong Jin
Chung, Min Young
Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title_full Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title_fullStr Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title_full_unstemmed Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title_short Association between Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients
title_sort association between diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178700/
https://www.ncbi.nlm.nih.gov/pubmed/21977459
http://dx.doi.org/10.4093/dmj.2011.35.4.390
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