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The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children
PURPOSE: Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178823/ https://www.ncbi.nlm.nih.gov/pubmed/21966605 http://dx.doi.org/10.4168/aair.2011.3.4.251 |
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author | Alyasin, Soheila Momen, Tooba Kashef, Sara Alipour, Abbass Amin, Reza |
author_facet | Alyasin, Soheila Momen, Tooba Kashef, Sara Alipour, Abbass Amin, Reza |
author_sort | Alyasin, Soheila |
collection | PubMed |
description | PURPOSE: Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated. METHODS: This cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6-18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients. RESULTS: Univariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R(2)=0.318; P=0.024) and FEV1/FVC (R(2)=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05). CONCLUSIONS: These results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D. |
format | Online Article Text |
id | pubmed-3178823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-31788232011-10-01 The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children Alyasin, Soheila Momen, Tooba Kashef, Sara Alipour, Abbass Amin, Reza Allergy Asthma Immunol Res Original Article PURPOSE: Asthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated. METHODS: This cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6-18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients. RESULTS: Univariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R(2)=0.318; P=0.024) and FEV1/FVC (R(2)=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05). CONCLUSIONS: These results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2011-10 2011-07-13 /pmc/articles/PMC3178823/ /pubmed/21966605 http://dx.doi.org/10.4168/aair.2011.3.4.251 Text en Copyright © 2011 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Alyasin, Soheila Momen, Tooba Kashef, Sara Alipour, Abbass Amin, Reza The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title_full | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title_fullStr | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title_full_unstemmed | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title_short | The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children |
title_sort | relationship between serum 25 hydroxy vitamin d levels and asthma in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178823/ https://www.ncbi.nlm.nih.gov/pubmed/21966605 http://dx.doi.org/10.4168/aair.2011.3.4.251 |
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