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Wavefront sensorless adaptive optics ophthalmoscopy in the human eye

Wavefront sensor noise and fidelity place a fundamental limit on achievable image quality in current adaptive optics ophthalmoscopes. Additionally, the wavefront sensor ‘beacon’ can interfere with visual experiments. We demonstrate real-time (25 Hz), wavefront sensorless adaptive optics imaging in t...

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Detalles Bibliográficos
Autores principales: Hofer, Heidi, Sredar, Nripun, Queener, Hope, Li, Chaohong, Porter, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178895/
https://www.ncbi.nlm.nih.gov/pubmed/21934779
http://dx.doi.org/10.1364/OE.19.014160
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author Hofer, Heidi
Sredar, Nripun
Queener, Hope
Li, Chaohong
Porter, Jason
author_facet Hofer, Heidi
Sredar, Nripun
Queener, Hope
Li, Chaohong
Porter, Jason
author_sort Hofer, Heidi
collection PubMed
description Wavefront sensor noise and fidelity place a fundamental limit on achievable image quality in current adaptive optics ophthalmoscopes. Additionally, the wavefront sensor ‘beacon’ can interfere with visual experiments. We demonstrate real-time (25 Hz), wavefront sensorless adaptive optics imaging in the living human eye with image quality rivaling that of wavefront sensor based control in the same system. A stochastic parallel gradient descent algorithm directly optimized the mean intensity in retinal image frames acquired with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO). When imaging through natural, undilated pupils, both control methods resulted in comparable mean image intensities. However, when imaging through dilated pupils, image intensity was generally higher following wavefront sensor-based control. Despite the typically reduced intensity, image contrast was higher, on average, with sensorless control. Wavefront sensorless control is a viable option for imaging the living human eye and future refinements of this technique may result in even greater optical gains.
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spelling pubmed-31788952011-09-23 Wavefront sensorless adaptive optics ophthalmoscopy in the human eye Hofer, Heidi Sredar, Nripun Queener, Hope Li, Chaohong Porter, Jason Opt Express Research-Article Wavefront sensor noise and fidelity place a fundamental limit on achievable image quality in current adaptive optics ophthalmoscopes. Additionally, the wavefront sensor ‘beacon’ can interfere with visual experiments. We demonstrate real-time (25 Hz), wavefront sensorless adaptive optics imaging in the living human eye with image quality rivaling that of wavefront sensor based control in the same system. A stochastic parallel gradient descent algorithm directly optimized the mean intensity in retinal image frames acquired with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO). When imaging through natural, undilated pupils, both control methods resulted in comparable mean image intensities. However, when imaging through dilated pupils, image intensity was generally higher following wavefront sensor-based control. Despite the typically reduced intensity, image contrast was higher, on average, with sensorless control. Wavefront sensorless control is a viable option for imaging the living human eye and future refinements of this technique may result in even greater optical gains. Optical Society of America 2011-07-11 /pmc/articles/PMC3178895/ /pubmed/21934779 http://dx.doi.org/10.1364/OE.19.014160 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Research-Article
Hofer, Heidi
Sredar, Nripun
Queener, Hope
Li, Chaohong
Porter, Jason
Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title_full Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title_fullStr Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title_full_unstemmed Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title_short Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
title_sort wavefront sensorless adaptive optics ophthalmoscopy in the human eye
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178895/
https://www.ncbi.nlm.nih.gov/pubmed/21934779
http://dx.doi.org/10.1364/OE.19.014160
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