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Proteases in Malaria Parasites - A Phylogenomic Perspective
Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial protease...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178910/ https://www.ncbi.nlm.nih.gov/pubmed/22379395 http://dx.doi.org/10.2174/138920211797248565 |
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author | Cai, Hong Kuang, Rui Gu, Jianying Wang, Yufeng |
author_facet | Cai, Hong Kuang, Rui Gu, Jianying Wang, Yufeng |
author_sort | Cai, Hong |
collection | PubMed |
description | Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasite life cycle and it is possible to design and screen for specific protease inhibitors. In this mini-review, we provide a phylogenomic overview of malarial proteases. An evolutionary perspective on the origin and divergence of these proteases will provide insights into the adaptive mechanisms of parasite growth, development, infection, and pathogenesis.B |
format | Online Article Text |
id | pubmed-3178910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-31789102012-03-01 Proteases in Malaria Parasites - A Phylogenomic Perspective Cai, Hong Kuang, Rui Gu, Jianying Wang, Yufeng Curr Genomics Article Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasite life cycle and it is possible to design and screen for specific protease inhibitors. In this mini-review, we provide a phylogenomic overview of malarial proteases. An evolutionary perspective on the origin and divergence of these proteases will provide insights into the adaptive mechanisms of parasite growth, development, infection, and pathogenesis.B Bentham Science Publishers 2011-09 /pmc/articles/PMC3178910/ /pubmed/22379395 http://dx.doi.org/10.2174/138920211797248565 Text en ©2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Cai, Hong Kuang, Rui Gu, Jianying Wang, Yufeng Proteases in Malaria Parasites - A Phylogenomic Perspective |
title | Proteases in Malaria Parasites - A Phylogenomic Perspective |
title_full | Proteases in Malaria Parasites - A Phylogenomic Perspective |
title_fullStr | Proteases in Malaria Parasites - A Phylogenomic Perspective |
title_full_unstemmed | Proteases in Malaria Parasites - A Phylogenomic Perspective |
title_short | Proteases in Malaria Parasites - A Phylogenomic Perspective |
title_sort | proteases in malaria parasites - a phylogenomic perspective |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178910/ https://www.ncbi.nlm.nih.gov/pubmed/22379395 http://dx.doi.org/10.2174/138920211797248565 |
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