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Herpes Simplex Ulcerative Esophagitis in Healthy Children

Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE) appears to be rare in the immunocompeten...

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Autores principales: Al-Hussaini, Abdulrahman A., Fagih, Mosa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178925/
https://www.ncbi.nlm.nih.gov/pubmed/21912064
http://dx.doi.org/10.4103/1319-3767.84496
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author Al-Hussaini, Abdulrahman A.
Fagih, Mosa A.
author_facet Al-Hussaini, Abdulrahman A.
Fagih, Mosa A.
author_sort Al-Hussaini, Abdulrahman A.
collection PubMed
description Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE) appears to be rare in the immunocompetent host. We report three cases of endoscopically-diagnosed HSVE in apparently immunocompetent children; the presentation was characterized by acute onset of fever, odynophagia, and dysphagia. In two cases, the diagnosis was confirmed histologically by identification of herpes viral inclusions and culture of the virus in the presence of inflammation. The third case was considered to have probable HSVE based on the presence of typical cold sore on his lip, typical endoscopic finding, histopathological evidence of inflammation in esophageal biopsies and positive serologic evidence of acute Herpes simplex virus infection. Two cases received an intravenous course of acyclovir and one had self-limited recovery. All three cases had normal immunological workup and excellent health on long-term follow-up.
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spelling pubmed-31789252011-10-03 Herpes Simplex Ulcerative Esophagitis in Healthy Children Al-Hussaini, Abdulrahman A. Fagih, Mosa A. Saudi J Gastroenterol Case Report Herpes simplex virus is a common cause of ulcerative esophagitis in the immunocompromised or debilitated host. Despite a high prevalence of primary and recurrent Herpes simplex virus infection in the general population, Herpes simplex virus esophagitis (HSVE) appears to be rare in the immunocompetent host. We report three cases of endoscopically-diagnosed HSVE in apparently immunocompetent children; the presentation was characterized by acute onset of fever, odynophagia, and dysphagia. In two cases, the diagnosis was confirmed histologically by identification of herpes viral inclusions and culture of the virus in the presence of inflammation. The third case was considered to have probable HSVE based on the presence of typical cold sore on his lip, typical endoscopic finding, histopathological evidence of inflammation in esophageal biopsies and positive serologic evidence of acute Herpes simplex virus infection. Two cases received an intravenous course of acyclovir and one had self-limited recovery. All three cases had normal immunological workup and excellent health on long-term follow-up. Medknow Publications 2011 /pmc/articles/PMC3178925/ /pubmed/21912064 http://dx.doi.org/10.4103/1319-3767.84496 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Al-Hussaini, Abdulrahman A.
Fagih, Mosa A.
Herpes Simplex Ulcerative Esophagitis in Healthy Children
title Herpes Simplex Ulcerative Esophagitis in Healthy Children
title_full Herpes Simplex Ulcerative Esophagitis in Healthy Children
title_fullStr Herpes Simplex Ulcerative Esophagitis in Healthy Children
title_full_unstemmed Herpes Simplex Ulcerative Esophagitis in Healthy Children
title_short Herpes Simplex Ulcerative Esophagitis in Healthy Children
title_sort herpes simplex ulcerative esophagitis in healthy children
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178925/
https://www.ncbi.nlm.nih.gov/pubmed/21912064
http://dx.doi.org/10.4103/1319-3767.84496
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