RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form

A rapid and sensitive reverse phase RP-HPLC method is proposed for the estimation of tamsulosin hydrochloride in tablets. Tamsulosin hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and water in the ratio of 50:50 v/v. The mobile phase wa...

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Detalles Bibliográficos
Autores principales: Kumari, Richa, Dash, P. P., Lal, V. K., Mishra, A., Murthy, P. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178983/
https://www.ncbi.nlm.nih.gov/pubmed/21969754
http://dx.doi.org/10.4103/0250-474X.84596
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author Kumari, Richa
Dash, P. P.
Lal, V. K.
Mishra, A.
Murthy, P. N.
author_facet Kumari, Richa
Dash, P. P.
Lal, V. K.
Mishra, A.
Murthy, P. N.
author_sort Kumari, Richa
collection PubMed
description A rapid and sensitive reverse phase RP-HPLC method is proposed for the estimation of tamsulosin hydrochloride in tablets. Tamsulosin hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and water in the ratio of 50:50 v/v. The mobile phase was pumped at a flow rate of 1.5 ml/min. The eluents were monitored at 214 nm. The retention time of the drug was 1.7 min. With this method, linearity was observed between area under curve and concentration of tamsulosin hydrochloride in the injected solution, in the range of 5 to 100 μg/ml. The method was found to be applicable for analysis of the drug in tablets. The results were validated statistically.
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spelling pubmed-31789832011-10-03 RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form Kumari, Richa Dash, P. P. Lal, V. K. Mishra, A. Murthy, P. N. Indian J Pharm Sci Short Communications A rapid and sensitive reverse phase RP-HPLC method is proposed for the estimation of tamsulosin hydrochloride in tablets. Tamsulosin hydrochloride was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and water in the ratio of 50:50 v/v. The mobile phase was pumped at a flow rate of 1.5 ml/min. The eluents were monitored at 214 nm. The retention time of the drug was 1.7 min. With this method, linearity was observed between area under curve and concentration of tamsulosin hydrochloride in the injected solution, in the range of 5 to 100 μg/ml. The method was found to be applicable for analysis of the drug in tablets. The results were validated statistically. Medknow Publications 2010 /pmc/articles/PMC3178983/ /pubmed/21969754 http://dx.doi.org/10.4103/0250-474X.84596 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Kumari, Richa
Dash, P. P.
Lal, V. K.
Mishra, A.
Murthy, P. N.
RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title_full RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title_fullStr RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title_full_unstemmed RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title_short RP – HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form
title_sort rp – hplc method for the estimation of tamsulosin hydrochloride in tablet dosage form
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178983/
https://www.ncbi.nlm.nih.gov/pubmed/21969754
http://dx.doi.org/10.4103/0250-474X.84596
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