A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form

A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as tw...

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Detalles Bibliográficos
Autores principales: Shah, S. A., Vyas, R. B., Vyas, B. A., Maniyar, N. R., Chauhan, R. S., Shah, D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178985/
https://www.ncbi.nlm.nih.gov/pubmed/21969756
http://dx.doi.org/10.4103/0250-474X.84599
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author Shah, S. A.
Vyas, R. B.
Vyas, B. A.
Maniyar, N. R.
Chauhan, R. S.
Shah, D. R.
author_facet Shah, S. A.
Vyas, R. B.
Vyas, B. A.
Maniyar, N. R.
Chauhan, R. S.
Shah, D. R.
author_sort Shah, S. A.
collection PubMed
description A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%.
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spelling pubmed-31789852011-10-03 A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form Shah, S. A. Vyas, R. B. Vyas, B. A. Maniyar, N. R. Chauhan, R. S. Shah, D. R. Indian J Pharm Sci Short Communications A simple, accurate, rapid, specific and reproducible UV spectrophotometric method was developed for estimation of content uniformity of atenolol and losartan potassium in its combined tablet dosage form. The method involves formation and solving the simultaneous equation using 226.4 and 254 nm as two wavelengths for atenolol and losartan, respectively. Developed method was employed to determine the atenolol and losartan content in ten individual tablet units of five market formulations. Methanol was used as solvent. The method was validated. From the results, it was concluded that all brands are within the content uniformity limit, 85-115%. Medknow Publications 2010 /pmc/articles/PMC3178985/ /pubmed/21969756 http://dx.doi.org/10.4103/0250-474X.84599 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Shah, S. A.
Vyas, R. B.
Vyas, B. A.
Maniyar, N. R.
Chauhan, R. S.
Shah, D. R.
A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title_full A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title_fullStr A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title_full_unstemmed A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title_short A Method for Content Uniformity Determination of Atenolol and Losartan Potassium in Combined Tablet Dosage Form
title_sort method for content uniformity determination of atenolol and losartan potassium in combined tablet dosage form
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178985/
https://www.ncbi.nlm.nih.gov/pubmed/21969756
http://dx.doi.org/10.4103/0250-474X.84599
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