Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets

A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F(254) with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilepha...

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Detalles Bibliográficos
Autores principales: Sundar, B. Syama, Suneetha, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178987/
https://www.ncbi.nlm.nih.gov/pubmed/21969758
http://dx.doi.org/10.4103/0250-474X.84601
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author Sundar, B. Syama
Suneetha, A.
author_facet Sundar, B. Syama
Suneetha, A.
author_sort Sundar, B. Syama
collection PubMed
description A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F(254) with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilephase. Quantitative analysis was performed by densitometric scanning at 230 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range 200-700 ng/band for rizatriptan benzoate. The method was successfully applied to the analysis of drug in bulk and marketed tablets.
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spelling pubmed-31789872011-10-03 Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets Sundar, B. Syama Suneetha, A. Indian J Pharm Sci Short Communications A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F(254) with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilephase. Quantitative analysis was performed by densitometric scanning at 230 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range 200-700 ng/band for rizatriptan benzoate. The method was successfully applied to the analysis of drug in bulk and marketed tablets. Medknow Publications 2010 /pmc/articles/PMC3178987/ /pubmed/21969758 http://dx.doi.org/10.4103/0250-474X.84601 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Sundar, B. Syama
Suneetha, A.
Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title_full Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title_fullStr Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title_full_unstemmed Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title_short Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets
title_sort development and validation of hptlc method for the estimation of rizatriptan benzoate in bulk and tablets
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178987/
https://www.ncbi.nlm.nih.gov/pubmed/21969758
http://dx.doi.org/10.4103/0250-474X.84601
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