Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives

A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl...

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Autores principales: Selvam, P., Murugesh, N., Chandramohan, M., Pannecouque, C., DE Clercq, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178989/
https://www.ncbi.nlm.nih.gov/pubmed/21969760
http://dx.doi.org/10.4103/0250-474X.84603
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author Selvam, P.
Murugesh, N.
Chandramohan, M.
Pannecouque, C.
DE Clercq, E.
author_facet Selvam, P.
Murugesh, N.
Chandramohan, M.
Pannecouque, C.
DE Clercq, E.
author_sort Selvam, P.
collection PubMed
description A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.
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spelling pubmed-31789892011-10-03 Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives Selvam, P. Murugesh, N. Chandramohan, M. Pannecouque, C. DE Clercq, E. Indian J Pharm Sci Short Communications A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses. Medknow Publications 2010 /pmc/articles/PMC3178989/ /pubmed/21969760 http://dx.doi.org/10.4103/0250-474X.84603 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Selvam, P.
Murugesh, N.
Chandramohan, M.
Pannecouque, C.
DE Clercq, E.
Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title_full Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title_fullStr Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title_full_unstemmed Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title_short Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives
title_sort synthesis, antiviral and cytotoxic activities of 2-(2-phenyl carboxylic acid)-3-phenylquinazolin -4(3h)-one derivatives
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178989/
https://www.ncbi.nlm.nih.gov/pubmed/21969760
http://dx.doi.org/10.4103/0250-474X.84603
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