A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matc...

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Autores principales: Popa, Olivia M., Bojinca, Mihai, Bojinca, Violeta, Dutescu, Monica I., Meirosu, Mihaela, Caisan, Ruxandra E., Ciofu, Claudia, Bara, Constantin, Popa, Luis O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179151/
https://www.ncbi.nlm.nih.gov/pubmed/21954344
http://dx.doi.org/10.3390/ijms12085052
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author Popa, Olivia M.
Bojinca, Mihai
Bojinca, Violeta
Dutescu, Monica I.
Meirosu, Mihaela
Caisan, Ruxandra E.
Ciofu, Claudia
Bara, Constantin
Popa, Luis O.
author_facet Popa, Olivia M.
Bojinca, Mihai
Bojinca, Violeta
Dutescu, Monica I.
Meirosu, Mihaela
Caisan, Ruxandra E.
Ciofu, Claudia
Bara, Constantin
Popa, Luis O.
author_sort Popa, Olivia M.
collection PubMed
description Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
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spelling pubmed-31791512011-09-27 A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population Popa, Olivia M. Bojinca, Mihai Bojinca, Violeta Dutescu, Monica I. Meirosu, Mihaela Caisan, Ruxandra E. Ciofu, Claudia Bara, Constantin Popa, Luis O. Int J Mol Sci Article Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients. Molecular Diversity Preservation International (MDPI) 2011-08-08 /pmc/articles/PMC3179151/ /pubmed/21954344 http://dx.doi.org/10.3390/ijms12085052 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Popa, Olivia M.
Bojinca, Mihai
Bojinca, Violeta
Dutescu, Monica I.
Meirosu, Mihaela
Caisan, Ruxandra E.
Ciofu, Claudia
Bara, Constantin
Popa, Luis O.
A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title_full A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title_fullStr A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title_full_unstemmed A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title_short A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population
title_sort pilot study of the association of tumor necrosis factor alpha polymorphisms with psoriatic arthritis in the romanian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179151/
https://www.ncbi.nlm.nih.gov/pubmed/21954344
http://dx.doi.org/10.3390/ijms12085052
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