Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the...

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Autores principales: Matsuura, Kazunori, Murasato, Kazuya, Kimizuka, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179159/
https://www.ncbi.nlm.nih.gov/pubmed/21954352
http://dx.doi.org/10.3390/ijms12085187
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author Matsuura, Kazunori
Murasato, Kazuya
Kimizuka, Nobuo
author_facet Matsuura, Kazunori
Murasato, Kazuya
Kimizuka, Nobuo
author_sort Matsuura, Kazunori
collection PubMed
description Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.
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spelling pubmed-31791592011-09-27 Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide Matsuura, Kazunori Murasato, Kazuya Kimizuka, Nobuo Int J Mol Sci Article Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water. Molecular Diversity Preservation International (MDPI) 2011-08-15 /pmc/articles/PMC3179159/ /pubmed/21954352 http://dx.doi.org/10.3390/ijms12085187 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Matsuura, Kazunori
Murasato, Kazuya
Kimizuka, Nobuo
Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title_full Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title_fullStr Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title_full_unstemmed Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title_short Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide
title_sort syntheses and self-assembling behaviors of pentagonal conjugates of tryptophane zipper-forming peptide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179159/
https://www.ncbi.nlm.nih.gov/pubmed/21954352
http://dx.doi.org/10.3390/ijms12085187
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