Mechanical Induction of PGE(2) in Osteocytes Blocks Glucocorticoid-Induced Apoptosis Through Both the β-Catenin and PKA Pathways

Glucocorticoids are known to induce osteocyte apoptosis, whereas mechanical loading has been shown to sustain osteocyte viability. Here we show that mechanical loading in the form of fluid-flow shear stress blocks dexamethasone-induced apoptosis of osteocyte-like cells (MLO-Y4). Prostaglandin E(2) (...

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Detalles Bibliográficos
Autores principales: Kitase, Yukiko, Barragan, Leonardo, Qing, Hai, Kondoh, Shino, Jiang, Jean X, Johnson, Mark L, Bonewald, Lynda F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179278/
https://www.ncbi.nlm.nih.gov/pubmed/20578217
http://dx.doi.org/10.1002/jbmr.168

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