Cargando…
Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight
Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179302/ https://www.ncbi.nlm.nih.gov/pubmed/21541997 http://dx.doi.org/10.1002/jbmr.289 |
_version_ | 1782212502302490624 |
---|---|
author | Zwart, Sara R Booth, Sarah L Peterson, James W Wang, Zuwei Smith, Scott M |
author_facet | Zwart, Sara R Booth, Sarah L Peterson, James W Wang, Zuwei Smith, Scott M |
author_sort | Zwart, Sara R |
collection | PubMed |
description | Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n= 6). In crew members who flew 2–6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21–90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight. © 2011 American Society for Bone and Mineral Research. |
format | Online Article Text |
id | pubmed-3179302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Wiley Subscription Services, Inc., A Wiley Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-31793022012-05-01 Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight Zwart, Sara R Booth, Sarah L Peterson, James W Wang, Zuwei Smith, Scott M J Bone Miner Res Original Article Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n= 6). In crew members who flew 2–6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21–90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight. © 2011 American Society for Bone and Mineral Research. Wiley Subscription Services, Inc., A Wiley Company 2011-05 2010-11-18 /pmc/articles/PMC3179302/ /pubmed/21541997 http://dx.doi.org/10.1002/jbmr.289 Text en Copyright © 2011 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Article Zwart, Sara R Booth, Sarah L Peterson, James W Wang, Zuwei Smith, Scott M Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title | Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title_full | Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title_fullStr | Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title_full_unstemmed | Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title_short | Vitamin K Status in Spaceflight and Ground-Based Models of Spaceflight |
title_sort | vitamin k status in spaceflight and ground-based models of spaceflight |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179302/ https://www.ncbi.nlm.nih.gov/pubmed/21541997 http://dx.doi.org/10.1002/jbmr.289 |
work_keys_str_mv | AT zwartsarar vitaminkstatusinspaceflightandgroundbasedmodelsofspaceflight AT boothsarahl vitaminkstatusinspaceflightandgroundbasedmodelsofspaceflight AT petersonjamesw vitaminkstatusinspaceflightandgroundbasedmodelsofspaceflight AT wangzuwei vitaminkstatusinspaceflightandgroundbasedmodelsofspaceflight AT smithscottm vitaminkstatusinspaceflightandgroundbasedmodelsofspaceflight |