Blockade of Receptor-Activated G(i) Signaling in Osteoblasts In Vivo Leads to Site-Specific Increases in Cortical and Cancellous Bone Formation

Osteoblasts play a critical role in the maintenance of bone mass through bone formation and regulation of bone resorption. Targeted expression of a constitutively active engineered G(i)-coupled G protein–coupled receptor (GPCR) to osteoblasts in vivo leads to severe osteopenia. However, little is kn...

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Detalles Bibliográficos
Autores principales: Millard, Susan M, Louie, Alyssa M, Wattanachanya, Lalita, Wronski, Thomas J, Conklin, Bruce R, Nissenson, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179326/
https://www.ncbi.nlm.nih.gov/pubmed/20939063
http://dx.doi.org/10.1002/jbmr.273

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