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Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration
BACKGROUND: Based on growing evidence that some adult multipotent cells necessary for tissue regeneration reside in the walls of blood vessels and the clinical success of vein wrapping for functional repair of nerve damage, we hypothesized that the repair of nerves via vein wrapping is mediated by c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179479/ https://www.ncbi.nlm.nih.gov/pubmed/21966370 http://dx.doi.org/10.1371/journal.pone.0024801 |
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author | Lavasani, Mitra Gehrmann, Sebastian Gharaibeh, Burhan Clark, Katherine A. Kaufmann, Robert A. Péault, Bruno Goitz, Robert J. Huard, Johnny |
author_facet | Lavasani, Mitra Gehrmann, Sebastian Gharaibeh, Burhan Clark, Katherine A. Kaufmann, Robert A. Péault, Bruno Goitz, Robert J. Huard, Johnny |
author_sort | Lavasani, Mitra |
collection | PubMed |
description | BACKGROUND: Based on growing evidence that some adult multipotent cells necessary for tissue regeneration reside in the walls of blood vessels and the clinical success of vein wrapping for functional repair of nerve damage, we hypothesized that the repair of nerves via vein wrapping is mediated by cells migrating from the implanted venous grafts into the nerve bundle. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis, severed femoral nerves of rats were grafted with venous grafts from animals of the opposite sex. Nerve regeneration was impaired when decellularized or irradiated venous grafts were used in comparison to untreated grafts, supporting the involvement of venous graft-derived cells in peripheral nerve repair. Donor cells bearing Y chromosomes integrated into the area of the host injured nerve and participated in remyelination and nerve regeneration. The regenerated nerve exhibited proper axonal myelination, and expressed neuronal and glial cell markers. CONCLUSIONS/SIGNIFICANCE: These novel findings identify the mechanism by which vein wrapping promotes nerve regeneration. |
format | Online Article Text |
id | pubmed-3179479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31794792011-09-30 Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration Lavasani, Mitra Gehrmann, Sebastian Gharaibeh, Burhan Clark, Katherine A. Kaufmann, Robert A. Péault, Bruno Goitz, Robert J. Huard, Johnny PLoS One Research Article BACKGROUND: Based on growing evidence that some adult multipotent cells necessary for tissue regeneration reside in the walls of blood vessels and the clinical success of vein wrapping for functional repair of nerve damage, we hypothesized that the repair of nerves via vein wrapping is mediated by cells migrating from the implanted venous grafts into the nerve bundle. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis, severed femoral nerves of rats were grafted with venous grafts from animals of the opposite sex. Nerve regeneration was impaired when decellularized or irradiated venous grafts were used in comparison to untreated grafts, supporting the involvement of venous graft-derived cells in peripheral nerve repair. Donor cells bearing Y chromosomes integrated into the area of the host injured nerve and participated in remyelination and nerve regeneration. The regenerated nerve exhibited proper axonal myelination, and expressed neuronal and glial cell markers. CONCLUSIONS/SIGNIFICANCE: These novel findings identify the mechanism by which vein wrapping promotes nerve regeneration. Public Library of Science 2011-09-23 /pmc/articles/PMC3179479/ /pubmed/21966370 http://dx.doi.org/10.1371/journal.pone.0024801 Text en Lavasani et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lavasani, Mitra Gehrmann, Sebastian Gharaibeh, Burhan Clark, Katherine A. Kaufmann, Robert A. Péault, Bruno Goitz, Robert J. Huard, Johnny Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title | Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title_full | Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title_fullStr | Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title_full_unstemmed | Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title_short | Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration |
title_sort | venous graft-derived cells participate in peripheral nerve regeneration |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179479/ https://www.ncbi.nlm.nih.gov/pubmed/21966370 http://dx.doi.org/10.1371/journal.pone.0024801 |
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