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Substrate Binding Process and Mechanistic Functioning of Type 1 11β-Hydroxysteroid Dehydrogenase from Enhanced Sampling Methods

In humans, type 1 11β-hydroxysteroid dehydrogenase (11β-HSD-1) plays a key role in the regulation of the glucocorticoids balance by converting the inactive hormone cortisone into cortisol. Numerous functional aspects of 11β-HSD-1 have been understood thanks to the availability at the Worldwide Prote...

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Detalles Bibliográficos
Autores principales:	Favia, Angelo D., Masetti, Matteo, Recanatini, Maurizio, Cavalli, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179505/ https://www.ncbi.nlm.nih.gov/pubmed/21966510 http://dx.doi.org/10.1371/journal.pone.0025375

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