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Hepatitis E Virus ORF2 Protein Activates the Pro-Apoptotic Gene CHOP and Anti-Apoptotic Heat Shock Proteins

BACKGROUND: Hepatitis E virus (HEV) is a non-enveloped plus-strand RNA virus that causes acute hepatitis. The capsid protein open reading frame 2 (ORF2) is known to induce endoplasmic reticulum stress in ORF2 expressing cells. METHODOLOGY/PRINCIPAL FINDINGS: In this study we found that HEV ORF2 acti...

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Detalles Bibliográficos
Autores principales:	John, Lijo, Thomas, Saijo, Herchenröder, Ottmar, Pützer, Brigitte M., Schaefer, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179511/ https://www.ncbi.nlm.nih.gov/pubmed/21966512 http://dx.doi.org/10.1371/journal.pone.0025378

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