Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of anti-diabetes drugs including rosiglitazone and pioglitazone(1). These drugs are full classical agonists for this nuclear receptor, but recent data has shown that many PPARγ-based drugs have a separate biochemical activity, b...

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Detalles Bibliográficos
Autores principales: Choi, Jang Hyun, Banks, Alexander S., Kamenecka, Theodore M., Busby, Scott A., Chalmers, Michael J., Kumar, Naresh, Kuruvilla, Dana S., Shin, Youseung, He, Yuanjun, Bruning, John B., Marciano, David P., Cameron, Michael D., Laznik, Dina, Jurczak, Michael J., Schürer, Stephan C., Vidović, Dušica, Shulman, Gerald I., Spiegelman, Bruce M., Griffin, Patrick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179551/
https://www.ncbi.nlm.nih.gov/pubmed/21892191
http://dx.doi.org/10.1038/nature10383

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